ID-4708 is a butyrophenone neuroleptic agent. It has the same structure as for trifluperidol but differs by the incorporation of an aniline amino group into the butyrophenone sidechain. Whereas trifluperidol is a Belgian drug developed at Janssen Pharmaceuticals, ID-4708 was developed by a Japanese company called Sumitomo Chemical in the 1970’s. ID-4708 when given at low doses reduced ambulation, while at higher doses defecation was inhibited.
Synthesis The chemical synthesis of ID-4708 was reported:
2-Acetylbutyrolactone [517-23-7] (1) 4-Fluoro-2-nitrobenzoic acid [394-01-4] (2) 4-Fluoro-2-nitrobenzoyl chloride [57750-82-0] (3) 3-(4-Fluoro-2-nitrobenzoyl)oxolan-2-one [62513-47-7] (4) 4-Bromo-1-(4-fluoro-2-nitrophenyl)butan-1-one [62513-48-8] (5) 2-(3-Bromopropyl)-2-(4-fluoro-2-nitrophenyl)-1,3-dioxolane [62513-50-2] (6) 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine [2249-28-7] (7) PC86735492 (8) PC70620175 (9)
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