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IL13RA2

IL13RA2 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand IL13RA2 rather than just read about it. In short: Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene. Function IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex.

IL13RA2 — main illustration
IL13RA2 — illustration

Key takeaways

  • IL13RA2 belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect IL13RA2 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of IL13RA2 from memory before moving on to harder problems.

Reference excerpt

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.

Function IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.

Clinical Significance IL-13Rα2 has been found to be over-expressed in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas.

See also Interleukin-13 receptor

References

Further reading

External links IL13RA2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural information available in the PDB for UniProt: Q14627 (Interleukin-13 receptor subunit alpha-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Illustrations

IL13RA2 illustration
IL13RA2 illustration
IL13RA2 illustration
IL13RA2 illustration
IL13RA2 illustration

Worked examples

Example 1 — a first encounter with IL13RA2

Start with the simplest possible case. Write down what IL13RA2 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to IL13RA2 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about IL13RA2 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of IL13RA2

In research
IL13RA2 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses IL13RA2 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
IL13RA2 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Clusters of differentiation, Genes on human chromosome X, Membrane protein stubs, so understanding it makes those chapters shorter.
In everyday life
Look for IL13RA2 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study IL13RA2 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what IL13RA2 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain IL13RA2 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is IL13RA2 in simple terms?

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene. Function IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex.

Why does IL13RA2 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study IL13RA2?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on IL13RA2.

Tags

  • Clusters of differentiation
  • Genes on human chromosome X
  • Membrane protein stubs

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