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chemistry

ISAM-140

ISAM-140 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand ISAM-140 rather than just read about it. In short: ISAM-140 is a selective non-xanthinic adenosine A2B receptor antagonist. Discovered in 2016, it has a Ki of 3.49 nM on the A2B receptor and >1000-fold selectivity with respect to the other three adenosine receptor subtypes.

ISAM-140 — main illustration
ISAM-140 — illustration

Key takeaways

  • ISAM-140 belongs to chemistry; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect ISAM-140 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of ISAM-140 from memory before moving on to harder problems.

Reference excerpt

ISAM-140 is a selective non-xanthinic adenosine A2B receptor antagonist. Discovered in 2016, it has a Ki of 3.49 nM on the A2B receptor and >1000-fold selectivity with respect to the other three adenosine receptor subtypes. It has been shown to help the immune system to attack cancer cells in in vitro assays by rescuing T and NK cell proliferation, cytokine release, and TIL infiltration.

References

Illustrations

ISAM-140 illustration

Worked examples

Example 1 — a first encounter with ISAM-140

Start with the simplest possible case. Write down what ISAM-140 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to ISAM-140 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about ISAM-140 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of ISAM-140

In research
ISAM-140 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses ISAM-140 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
ISAM-140 is common in secondary-school and first-year university syllabi. It links to neighbouring topics 2-Furyl compounds, Esters, Heterocyclic compounds with 3 rings, so understanding it makes those chapters shorter.
In everyday life
Look for ISAM-140 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study ISAM-140 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what ISAM-140 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain ISAM-140 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is ISAM-140 in simple terms?

ISAM-140 is a selective non-xanthinic adenosine A2B receptor antagonist. Discovered in 2016, it has a Ki of 3.49 nM on the A2B receptor and >1000-fold selectivity with respect to the other three adenosine receptor subtypes.

Why does ISAM-140 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study ISAM-140?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on ISAM-140.

Tags

  • 2-Furyl compounds
  • Esters
  • Heterocyclic compounds with 3 rings
  • Nitrogen heterocycles

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