chemistry

Ibogalog

Ibogalog is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Ibogalog rather than just read about it. In short: An ibogalog, or simplified ibogaine analogue, also known as a substituted 1,2,3,4,5,6-hexahydroazepino[4,5-b]indole (or simply substituted hexahydroazepinoindole), is a derivative of noribogaminalog and a simplified analogue of iboga alkaloids and related compounds such as ibogaine. They are tricyclic cyclized tryptamines and are closely related to the β-carbolines or harmala alkaloids.

Key takeaways

Ibogalog belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Ibogalog to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Ibogalog from memory before moving on to harder problems.

Reference excerpt

An ibogalog, or simplified ibogaine analogue, also known as a substituted 1,2,3,4,5,6-hexahydroazepino[4,5-b]indole (or simply substituted hexahydroazepinoindole), is a derivative of noribogaminalog and a simplified analogue of iboga alkaloids and related compounds such as ibogaine. They are tricyclic cyclized tryptamines and are closely related to the β-carbolines or harmala alkaloids. However, ibogalogs have a mostly-hydrogenated 7-membered azepine ring instead of the variably-saturated 6-membered pyridine ring present in β-carbolines. Relative to the iboga alkaloids, ibogalogs retain the indole and hydrogenated azepine rings, but the isoquinuclidine (2-azabicyclo[2.2.2]octane) ring system has been removed, simplifying the chemical structure.

Use and effects Ibogalogs have been limitedly tested in humans, but anecdotal reports concerning tabernanthalog exist.

Interactions

Pharmacology

Pharmacodynamics Ibogalogs are known to act as potent serotonin 5-HT2A and 5-HT2C receptor agonists, as well as acting as agonists of other serotonin receptors. This is in contrast to iboga alkaloids like ibogaine and noribogaine, which are inactive as serotonin receptor agonists. Ibogalogs also possess other actions, such as serotonin 5-HT2B receptor antagonism or partial agonism, monoamine reuptake inhibition, and nicotinic acetylcholine receptor inhibition. Unlike iboga alkaloids like noribogaine, they show no opioid receptor agonism, for instance of the κ-opioid receptor. In addition, the compounds have dramatically reduced potency at the hERG antitarget compared to ibogaine, which confers much less cardiotoxicity. Ibogalogs have been reported to produce psychoplastogenic, antidepressant-like, anxiolytic-like, sedative-like, antiaddictive-like, and analgesic effects in animals. Based on the rodent head-twitch response, a behavioral proxy of serotonergic psychedelic activity, ibogainalog may produce psychedelic effects in humans, while other assessed ibogainalogs, including tabernanthalog, ibogaminalog, noribogainalog, and catharanthalog, appear to be non-psychedelic. In addition, PNU-22394 was non-hallucinogenic in clinical studies.

History Ibogalogs, such as PNU-22394, were first developed and described in the 1960s. In the early 2000s, ibogalogs like PNU-22394 were studied and described further as potential appetite suppressants and weight loss drugs. Subsequently, ibogalogs were studied and described in the early 2020s and thereafter, including by David E. Olson and colleagues at the University of California, Davis and Delix Therapeutics, as potential treatments of central nervous system disorders. Relatedly, tabernanthalog (TBG; DLX-007) is under development for potential medical use.

List of ibogalogs

Related compounds

See also Azepinoindole Iboga alkaloid 5-MeO-IsoqT Oxa-noribogaine Substituted β-carboline Substituted 3-benzazepine Substituted tetrahydroisoquinoline Non-hallucinogenic 5-HT2A receptor agonist

References

Illustrations

Worked examples

Example 1 — a first encounter with Ibogalog

Start with the simplest possible case. Write down what Ibogalog claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Ibogalog before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Ibogalog ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Ibogalog

In research: Ibogalog appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Ibogalog in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Ibogalog is common in secondary-school and first-year university syllabi. It links to neighbouring topics Chemical classes of psychoactive drugs, Ibogalogs, so understanding it makes those chapters shorter.
In everyday life: Look for Ibogalog outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Ibogalog in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Ibogalog means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Ibogalog out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Ibogalog in simple terms?

Why does Ibogalog matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Ibogalog?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Ibogalog.