Icafolin-methyl is a post-emergent chemical herbicide developed by Bayer. It is a methyl ester derivative of icafolin and has the formula C18H18F2N2O5. The herbicide was patented in 2022, registered in 2025, and is anticipated to be introduced in 2028 for use in Brazil. It is a tubulin inhibitor that may be applied to cereals, oilseeds and soybeans, and is described as being effective against monocotyledonous and dicotyledonous weeds, with examples being sourgrass and barnyardgrass. The herbicide is synthesized as a mixture of (2R,4R) and (2S,4S) stereoisomers through a multi-step process. Icafolin-methyl is hydrolyzed to icafolin in plants.
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