chemistry

Iclepertin

Iclepertin is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Iclepertin rather than just read about it. In short: Iclepertin (developmental code name BI 425809) is an investigational nootropic to enhance the cognition and functional capacity in schizophrenia developed by Boehringer Ingelheim. As of May 2020, it is in phase III of clinical trial under the code name CONNEX-3.

Key takeaways

Iclepertin belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Iclepertin to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Iclepertin from memory before moving on to harder problems.

Reference excerpt

Iclepertin (developmental code name BI 425809) is an investigational nootropic to enhance the cognition and functional capacity in schizophrenia developed by Boehringer Ingelheim. As of May 2020, it is in phase III of clinical trial under the code name CONNEX-3. BI 425809 is an inhibitor of glycine transporter 1 (Gly-T1) that in phase II improved cognition after 12 weeks in patients with schizophrenia. Doses of 10 mg and 25 mg showed the largest separation from placebo. If these encouraging results are confirmed in phase 3 trials, BI 425809 could provide an effective treatment for cognitive impairment associated with schizophrenia. Schizophrenia is characterized by abnormalities in glutamatergic pathways related to NMDA receptor hypofunction. Inhibition of GlyT1 on the presynaptic membrane or astrocytes is hypothesized to increase glycine levels within the synapse. The NMDA receptor function may be enhanced by increasing levels of its co-agonist, glycine, within the synaptic cleft, which may lead to improvements in cognitive function. In January 2025, Boehringer Ingelheim announced that the phase 3 program CONNEX missed both the primary and key secondary endpoints. When compared to placebo at six months, patients receiving the Iclepertin drug do not have statistically significant effects in improving cognitive impairment. The laboratory announced stopping a related long-term extension study.

See also List of investigational antipsychotics List of investigational cognition and memory disorder drugs

References

Illustrations

Worked examples

Example 1 — a first encounter with Iclepertin

Start with the simplest possible case. Write down what Iclepertin claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Iclepertin before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Iclepertin ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Iclepertin

In research: Iclepertin appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Iclepertin in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Iclepertin is common in secondary-school and first-year university syllabi. It links to neighbouring topics Cyclopropanes, Experimental drugs developed for schizophrenia, Glycine reuptake inhibitors, so understanding it makes those chapters shorter.
In everyday life: Look for Iclepertin outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Iclepertin in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Iclepertin means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Iclepertin out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Iclepertin in simple terms?

Why does Iclepertin matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Iclepertin?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Iclepertin.