biology

Ihor R. Lemischka

Ihor R. Lemischka is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Ihor R. Lemischka rather than just read about it. In short: Ihor R. Lemischka was an American stem cell biologist and stem cell research advocate and was both the Lillian and Henry M.

Key takeaways

Ihor R. Lemischka belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Ihor R. Lemischka to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Ihor R. Lemischka from memory before moving on to harder problems.

Reference excerpt

Ihor R. Lemischka was an American stem cell biologist and stem cell research advocate and was both the Lillian and Henry M. Stratton Professor of Gene and Cell Medicine and Director of the Black Family Stem Cell Institute at Mount Sinai Medical Center in New York City. His work with hematopoietic stem cells (HSC) was the first to identify their novel receptor tyrosine kinases and showed that HSC can rebuild all blood cell types in a mouse whose blood cells had been destroyed. He authored over 70 book chapters and publications in peer-reviewed journals.

Biography

Education and post-doctoral training Lemischka graduated from Johns Hopkins University in 1976 and earned his Ph.D. in biology from MIT in 1983. He did his post-doctoral training at MIT's Whitehead Institute.

Academic appointments Lemischka joined Princeton University in 1986 as Assistant Professor of Molecular Biology; he became Professor in 2002. In 2007, he joined the staff at Mount Sinai Medical Center, where he was Professor of Gene and Cell Medicine and Director of the Black Family Stem Cell Institute.

Affiliations and awards Lemischka was a board member of the International Society for Stem Cell Research, the Journal of Visualized Experiments (JoVE) and the New York Stem Cell Foundation. His awards included a Damon Runyon-Walter Winchell Postdoctoral, a Leukemia Social Special Fellowship, an American Cyanamid Preceptorship Award and the DuPont Young Faculty Grant. He was a journal reviewer for Cell, Science, Nature, Nature Genetics, Nature Immunology, Nature Biotechnology, Proceedings of the National Academy of Sciences, Public Library of Science, Development, Genes & Development, Journal of Clinical Investigation and Blood.

Patents Lemischka held or had patents pending for the following:

Areas of concentration Lemischka's interests included defining the cellular and molecular mechanisms that control cell fate decisions in embryonic stem cells. Research into mouse embryonic stem cells was aggressively studied in the embryonic stem cells of humans.

Publications Partial List:

Fasano CA, Dimos JT, Ivanova NB, Lowry N, Lemischka IR, Temple S (June 2007). "shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development". Cell Stem Cell. 1 (1): 87–99. doi:10.1016/j.stem.2007.04.001. PMID 18371338.{{cite journal}}: CS1 maint: multiple names: authors list (link) (Retracted, see doi:10.1016/j.stem.2023.05.009, PMID 37267919) Ivanova N, Dobrin R, Lu R; et al. (August 2006). "Dissecting self-renewal in stem cells with RNA interference". Nature. 442 (7102): 533–8. Bibcode:2006Natur.442..533I. doi:10.1038/nature04915. PMID 16767105.{{cite journal}}: CS1 maint: multiple names: authors list (link) Moore KA, Lemischka IR (March 2006). "Stem cells and their niches". Science. 311 (5769): 1880–5. Bibcode:2006Sci...311.1880M. doi:10.1126/science.1110542. PMID 16574858. Schaniel C, Li F, Schafer XL, Moore T, Lemischka IR, Paddison PJ (May 2006). "Delivery of short hairpin RNAs--triggers of gene silencing--into mouse embryonic stem cells". Nat. Methods. 3 (5): 397–400. doi:10.1038/nmeth0506-397. PMID 16628211.{{cite journal}}: CS1 maint: multiple names: authors list (link) Pritsker M, Ford NR, Jenq HT, Lemischka IR (May 2006). "Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells". Proc. Natl. Acad. Sci. U.S.A. 103 (18): 6946–51. Bibcode:2006PNAS..103.6946P. doi:10.1073/pnas.0509861103. PMC 1458999. PMID 16621925.{{cite journal}}: CS1 maint: multiple names: authors list (link) Shen Q, Wang Y, Dimos JT; et al. (June 2006). "The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells". Nat. Neurosci. 9 (6): 743–51. doi:10.1038/nn1694. PMID 16680166.{{cite journal}}: CS1 maint: multiple names: authors list (link) Pritsker M, Doniger TT, Kramer LC, Westcot SE, Lemischka IR (October 2005). "Diversification of stem cell molecular repertoire by alternative splicing". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14290–5. Bibcode:2005PNAS..10214290P. doi:10.1073/pnas.0502132102. PMC 1242282. PMID 16183747.{{cite journal}}: CS1 maint: multiple names: authors list (link) Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR (October 2002). "A stem cell molecular signature". Science. 298 (5593): 601–4. Bibcode:2002Sci...298..601I. doi:10.1126/science.1073823. PMID 12228721.{{cite journal}}: CS1 maint: multiple names: authors list (link) Phillips RL, Ernst RE, Brunk B, Ivanova N, Mahan MA, Deanehan JK, Moore KA, Overton GC, Lemischka IR (2000). "The Genetic Program of Hematopoietic Stem Cells". Science. 288 (5471): 1635–1640. Bibcode:2000Sci...288.1635P. doi:10.1126/science.288.5471.1635. PMID 10834841.{{cite journal}}: CS1 maint: multiple names: authors list (link) Petrenko O, Beavis A, Klaine M, Godin I, Lemischka IR (1999). "The molecular characterization of the fetal stem cell marker AA4". Immunity. 10 (6): 691–700. doi:10.1016/S1074-7613(00)80068-0. PMID 10403644.{{cite journal}}: CS1 maint: multiple names: authors list (link)

References

External links Mount Sinai Hospital homepage Mount Sinai School of Medicine homepage Control and Regulation of Stem Cells – interview with Catherine Cormier, SciVee Dissecting Cell Fate Regulation in Stem Cells, YouTube Stem Cell Research: An NPR Special Report, National Public Radio Stem Cells Meet Systems Biology, Nature Reports Princeton scientists explore the next frontier of stem cell research, Princeton Weekly Bulletin No Stem Cell Left Behind, New York Times

Illustrations

Worked examples

Example 1 — a first encounter with Ihor R. Lemischka

Start with the simplest possible case. Write down what Ihor R. Lemischka claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Ihor R. Lemischka before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Ihor R. Lemischka ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Ihor R. Lemischka

In research: Ihor R. Lemischka appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Ihor R. Lemischka in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Ihor R. Lemischka is common in secondary-school and first-year university syllabi. It links to neighbouring topics 21st-century American biologists, American medical academics, American people of Belarusian descent, so understanding it makes those chapters shorter.
In everyday life: Look for Ihor R. Lemischka outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Ihor R. Lemischka in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Ihor R. Lemischka means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
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Frequently asked questions

What is Ihor R. Lemischka in simple terms?

Ihor R. Lemischka was an American stem cell biologist and stem cell research advocate and was both the Lillian and Henry M.

Why does Ihor R. Lemischka matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Ihor R. Lemischka?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Ihor R. Lemischka.