Iminodibenzyl is an aromatic organic compound with a multitude of uses in medicinal chemistry. Iminodibenzyl is a fundamental building block used mainly in the construction of tricyclic antidepressants. Chemically speaking, it is almost the same as for iminostilbene, but differs in that the 2 carbon bridge between the two phenyl rings is saturated (with hydrogen), and does not contain an olefin.
Applications
DDD-025 Bonnecor Carbamazepine Carpipramine Ciclopramine Cianopramine Clomipramine & Clocapramine & Mosapramine Depramine Desipramine & Didesipramine [2095-95-6] Homopipramol Imipramine & Imipraminoxide Ketipramine Lofepramine Metapramine Opipramol Oxcarbazepine Quinupramine Trimipramine
Synthesis The synthesis of iminodibenzyl has been discussed:
The treatment of 2-Nitrotoluene [88-72-2] (1) with amyl nitrite or Isopentyl formate [110-45-2] and potassium tert-butoxide resulted in an “oxidative coupling” to give 2,2'-Dinitrodibenzyl [16968-19-7] (2). Catalytic hydrogenation of both nitro groups gives 2,2'-Ethylenedianiline [34124-14-6] (4). Treatment with phosphoric acid then completes the synthesis of iminodibenzyl (5). Additional Chinese patents:
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