science

Indiplon

Indiplon is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Indiplon rather than just read about it. In short: Indiplon (INN and USAN) is an unmarketed nonbenzodiazepine, hypnotic sedative that was developed in two formulations—an immediate-release formulation for sleep onset, and a modified-release (also called controlled-release or extended-release) version for sleep maintenance. Pharmacology Pharmacodynamics Indiplon works by enhancing the action of the inhibitory neurotransmitter GABA, like most other nonbenzodiazepine s…

Key takeaways

Indiplon belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Indiplon to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Indiplon from memory before moving on to harder problems.

Reference excerpt

Indiplon (INN and USAN) is an unmarketed nonbenzodiazepine, hypnotic sedative that was developed in two formulations—an immediate-release formulation for sleep onset, and a modified-release (also called controlled-release or extended-release) version for sleep maintenance.

Pharmacology

Pharmacodynamics Indiplon works by enhancing the action of the inhibitory neurotransmitter GABA, like most other nonbenzodiazepine sedatives. It primarily binds to benzodiazepine sites on α1 subunit-containing GABAA receptors in the brain.

Pharmacokinetics Indiplon has a short elimination half-life of 1.5 to 1.8 hours in young and elderly subjects, respectively.

Chemistry Indiplon is a pyrazolopyrimidine related to the nonbenzodiazepine hypnotic zaleplon.

History Indiplon was discovered at Lederle Laboratories (which was later acquired by Wyeth) in the 1980s and was called CL 285,489. In 1998 Lederle licensed it, along with other early stage drug candidates, to DOV Pharmaceutical, a startup formed by former Lederle employees, and Dov exclusively sublicensed its rights in the drug to Neurocrine Biosciences in that same year. In 2002, Neurocrine entered into an agreement with Pfizer to develop the drug. Indiplon was originally scheduled for release in 2007, when Sanofi-Aventis' popular hypnotic zolpidem lost its patent rights in the United States and thus became available as a much less expensive generic. In 2002, Neurocrine Biosciences had entered into an agreement with Pfizer to co-market indiplon in the US, in a deal worth a potential $400mn. However, following the issuing of a non-approvable letter for the modified-release 15 mg formulation and an approvable letter with stipulations for the 5 mg and 10 mg immediate-release version by the FDA in May 2006, Pfizer ended its relationship with Neurocrine. Neurocrine's stock price dropped 60% on the news. Following a resubmission, the FDA in December 2007 deemed Neurocrine's new drug application (NDA) 'approvable' in the 5 and 10 mg formulations, but requested new studies as a prerequisite to approval, including a clinical trial in the elderly, a safety study comparing adverse effects to those of similarly marketed drugs, and a preclinical study examining indiplon's safety in the third trimester of pregnancy. Following the 2007 FDA letter, Neurocrine decided to discontinue all clinical and marketing development of Indiplon in the United States.

References

External links 2004 press release announcing Neurocrine's new product, Indiplon GenomeNet Entry: D02640

Illustrations

Worked examples

Example 1 — a first encounter with Indiplon

Start with the simplest possible case. Write down what Indiplon claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Indiplon before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Indiplon ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Indiplon

In research: Indiplon appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Indiplon in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Indiplon is common in secondary-school and first-year university syllabi. It links to neighbouring topics Acetanilides, Diarylketones, Drugs not assigned an ATC code, so understanding it makes those chapters shorter.
In everyday life: Look for Indiplon outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Indiplon in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Indiplon means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Indiplon out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Indiplon in simple terms?

Why does Indiplon matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Indiplon?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Indiplon.