In enzymology, indole-3-acetaldehyde reductase (NADPH) (EC 1.1.1.191) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are [tryptophol and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are indole-3-acetaldehyde, reduced NADPH, and a proton. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (indol-3-yl)ethanol:NADP+ oxidoreductase. Other names in common use include indoleacetaldehyde (reduced nicotinamide adenine dinucleotide, phosphate) reductase, indole-3-acetaldehyde reductase (NADPH), and indole-3-ethanol:NADP+ oxidoreductase. This enzyme participates in tryptophan metabolism.
See also Indole-3-acetaldehyde reductase (NADH) which catalyses the same reaction with the cofactor nicotinamide adenine dinucleotide
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