Ineffective erythropoiesis a condition in which the bone marrow produces red blood cells (erythrocytes) that are unable to mature properly and are pre-maturely destroyed due to various causes. Erythropoiesis is the overall process that the body goes through to produce red blood cells. The red blood cell's main function is to carry and transport oxygen from the lungs to tissues throughout the body. If the red blood cells are unable to mature properly or are destroyed pre-maturely, this can lead to anemia. This mechanism is principally responsible for the anemia seen in acquired conditions such as certain subtypes of myelodysplastic syndrome (MDS) and inherited disorders such as β-thalassemia, inherited sideroblastic anemias, as well as congenital dyserythropoietic anemias.
See also Congenital dyserythropoietic anemias List of hematologic conditions
References
Further reading Ribeil, Jean-Antoine; Arlet, Jean-Benoit; Dussiot, Michael; Cruz Moura, Ivan; Courtois, Geneviève; Hermine, Olivier (28 March 2013). "Ineffective Erythropoiesis in β-Thalassemia". The Scientific World Journal. 2013 e394295. doi:10.1155/2013/394295. ISSN 2356-6140. PMC 3628659. PMID 23606813. Tanno, Toshihiko; Miller, Jeffery L. (11 May 2010). "Iron Loading and Overloading due to Ineffective Erythropoiesis". Advances in Hematology. 2010 e358283. doi:10.1155/2010/358283. ISSN 1687-9104. PMC 2868182. PMID 20467559. Rivella, Stefano (2013). "Ineffective erythropoiesis and thalassemias". Current Opinion in Hematology. 16 (3): 187–194. doi:10.1097/MOH.0b013e32832990a4. ISSN 1065-6251. PMC 3703923. PMID 19318943. Gupta, Ritama; Musallam, Khaled M.; Taher, Ali T.; Rivella, Stefano (2019). "Ineffective Erythropoiesis, Anemia and Iron Overload". Hematology/Oncology Clinics of North America. 32 (2): 213–221. doi:10.1016/j.hoc.2017.11.009. ISSN 0889-8588. PMC 5824437. PMID 29458727.
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