biology

Interleukin 20 receptor, alpha subunit

Interleukin 20 receptor, alpha subunit is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Interleukin 20 receptor, alpha subunit rather than just read about it. In short: Interleukin 20 receptor, alpha subunit, is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor. The interleukin 20 receptor, alpha subunit is also referred to as IL20R1 or IL20RA.

Key takeaways

Interleukin 20 receptor, alpha subunit belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Interleukin 20 receptor, alpha subunit to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Interleukin 20 receptor, alpha subunit from memory before moving on to harder problems.

Reference excerpt

Interleukin 20 receptor, alpha subunit, is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor. The interleukin 20 receptor, alpha subunit is also referred to as IL20R1 or IL20RA. The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway.

Tissue distribution IL20RA is found in the skin, lungs, ovaries, testes and placenta, with low gene expression in the intestine and liver. IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RA is also found in some immune cells.

Structure and function IL20RA is an alpha-chain with a long intracellular domain. IL20RA, along with the IL-20 receptor, beta subunit, form the heterodimeric interleukin-20 receptor, which binds the cytokines IL-19, IL-20 and IL-24. IL20RA also forms a complex with the IL-10 receptor, beta subunit, which binds the cytokine IL-26.

Signaling Receptors made up of IL20RA signal through a JAK-STAT signaling pathway. In this pathway, after a cytokine binds IL20RA and the beta subunit, JAKs linked to intracellular domains of IL20R activate and phosphorylate tyrosine residues found in the longer alpha chains of IL20RA. STAT then binds to docking sites created by JAK phosphorylation and becomes phosphorylated by JAK. STATs then dimerize and move to the nucleus to act as transcription factors. The specific genes expressed are dependent on the specific JAK, STAT, as well as by SOCS proteins, which can inhibit the JAK-STAT signal, regulating it.where the transcription factor STAT3 binds to IL20RA and STAT3 becomes activated.[1] IL20RA has multiple docking sites for STAT3.

Clinical significance Research indicates that IL20RA is found in some immune cells. For example, IL20RA is sometimes found in lung macrophages. Research indicates that IL20RA presence may be related to disease. In people with rheumatoid arthiritis, IL20RA is present in blood monocytes. IL20RA has also been linked with psoriasis, and atherosclerosis, all diseases associated with inflammation. The specific role of IL20RA in these diseases is unknown.

References

Illustrations

Worked examples

Example 1 — a first encounter with Interleukin 20 receptor, alpha subunit

Start with the simplest possible case. Write down what Interleukin 20 receptor, alpha subunit claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Interleukin 20 receptor, alpha subunit before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Interleukin 20 receptor, alpha subunit ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Interleukin 20 receptor, alpha subunit

In research: Interleukin 20 receptor, alpha subunit appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Interleukin 20 receptor, alpha subunit in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Interleukin 20 receptor, alpha subunit is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 6, Human chromosome 6 gene stubs, Type II cytokine receptors, so understanding it makes those chapters shorter.
In everyday life: Look for Interleukin 20 receptor, alpha subunit outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Interleukin 20 receptor, alpha subunit in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Interleukin 20 receptor, alpha subunit means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Interleukin 20 receptor, alpha subunit out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Interleukin 20 receptor, alpha subunit in simple terms?

Why does Interleukin 20 receptor, alpha subunit matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Interleukin 20 receptor, alpha subunit?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Interleukin 20 receptor, alpha subunit.