biology

Interleukin 8 receptor, alpha

Interleukin 8 receptor, alpha is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Interleukin 8 receptor, alpha rather than just read about it. In short: Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 and the approved symbol CXCR1.

Key takeaways

Interleukin 8 receptor, alpha belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Interleukin 8 receptor, alpha to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Interleukin 8 receptor, alpha from memory before moving on to harder problems.

Reference excerpt

Interleukin 8 receptor, alpha is a chemokine receptor. This name and the corresponding gene symbol IL8RA have been replaced by the HGNC approved name C-X-C motif chemokine receptor 1 and the approved symbol CXCR1. It has also been designated as CD181 (cluster of differentiation 181). The IUPHAR Committee on Receptor Nomenclature and Drug Classification use the HGNC recommended name, CXCR1.

Function The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. IL8RA, IL8RB, which encodes another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Stimulation of CXCR1 in neutrophils by its primary ligand, Interleukin 8, leads to neutrophil chemotaxis and activation.

Clinical significance Blocking CXCR1 (e.g., with repertaxin) inhibits some human breast cancer stem cells (in vitro and in mice). In melanoma expression of CXCR1 at the cell surface is present, independent of the cancers stage. It is thought to have a role in the cell growth and angiogenesis required for tumour survival. In this way it has been identified as a potential therapeutic target. CXCR1 can be cleaved and inactivated by Neutrophil Derived Serine Proteases (NSPs), leading to neutrophil dysfunction and impaired bacterial killing in cystic fibrosis lung disease.

Interactions Interleukin 8 receptor, alpha has been shown to interact with GNAI2.

See also Interleukin Interleukin 8 Interleukin 8 receptor, beta Interleukin receptor Interleukin-8 receptor

References

Illustrations

Worked examples

Example 1 — a first encounter with Interleukin 8 receptor, alpha

Start with the simplest possible case. Write down what Interleukin 8 receptor, alpha claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Interleukin 8 receptor, alpha before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Interleukin 8 receptor, alpha ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Interleukin 8 receptor, alpha

In research: Interleukin 8 receptor, alpha appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Interleukin 8 receptor, alpha in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Interleukin 8 receptor, alpha is common in secondary-school and first-year university syllabi. It links to neighbouring topics Chemokine receptors, Clusters of differentiation, Genes on human chromosome 2, so understanding it makes those chapters shorter.
In everyday life: Look for Interleukin 8 receptor, alpha outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Interleukin 8 receptor, alpha in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Interleukin 8 receptor, alpha means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Interleukin 8 receptor, alpha out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Interleukin 8 receptor, alpha in simple terms?

Why does Interleukin 8 receptor, alpha matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Interleukin 8 receptor, alpha?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Interleukin 8 receptor, alpha.