Isobucaine is a local anesthetic.
Synthesis
The reductive amination between aminomethyl propanol (1) and isobutanal [78-84-2] (2) afforded N-Isobutyl-1,1-dimethyl-2-hydroxyethanamine, CID:18315986 (3). Acylation of the amine with benzoyl chloride [98-88-4] hypothetically goes initially to the amide (4'). The acid catalysis used in the reaction leads to an N to O acyl migration to afford isobucaine (5).
See also List of local anesthetics
References


![Isobucaine: Synthesis:[2]](https://upload.wikimedia.org/wikipedia/commons/thumb/3/38/Isobucaine_synthesis.svg/500px-Isobucaine_synthesis.svg.png?utm_source=en.wikipedia.org&utm_campaign=parser&utm_content=thumbnail)
