engineering

Isocitrate dehydrogenase (NADP+) kinase

Isocitrate dehydrogenase (NADP+) kinase is a engineering topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Isocitrate dehydrogenase (NADP+) kinase rather than just read about it. In short: In enzymology, a [isocitrate dehydrogenase (NADP+)] kinase (EC 2.7.11.5) is an enzyme that catalyzes the chemical reaction: ATP + [isocitrate dehydrogenase (NADP+)] ⇌ {\displaystyle \rightleftharpoons } ADP + [isocitrate dehydrogenase (NADP+)] phosphate Thus, the two substrates of this enzyme are ATP and isocitrate dehydrogenase (NADP+), whereas its two products are ADP and isocitrate dehydrogenase (NADP+) phosphate…

Key takeaways

Isocitrate dehydrogenase (NADP+) kinase belongs to engineering; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Isocitrate dehydrogenase (NADP+) kinase to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Isocitrate dehydrogenase (NADP+) kinase from memory before moving on to harder problems.

Reference excerpt

In enzymology, a [isocitrate dehydrogenase (NADP+)] kinase (EC 2.7.11.5) is an enzyme that catalyzes the chemical reaction:

ATP + [isocitrate dehydrogenase (NADP+)] ⇌ {\displaystyle \rightleftharpoons } ADP + [isocitrate dehydrogenase (NADP+)] phosphate Thus, the two substrates of this enzyme are ATP and isocitrate dehydrogenase (NADP+), whereas its two products are ADP and isocitrate dehydrogenase (NADP+) phosphate. This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases).

Other names The systematic name of this enzyme class is ATP:[isocitrate dehydrogenase (NADP+)] phosphotransferase. Other names in common use include [isocitrate dehydrogenase (NADP+)] kinase, ICDH kinase/phosphatase, IDH kinase, IDH kinase/phosphatase, IDH-K/P, IDHK/P, isocitrate dehydrogenase kinase (phosphorylating), isocitrate dehydrogenase kinase/phosphatase, and STK3.

References Wang JY, Koshland DE (1982). "The reversible phosphorylation of isocitrate dehydrogenase of Salmonella typhimurium". Arch. Biochem. Biophys. 218 (1): 59–67. doi:10.1016/0003-9861(82)90321-6. PMID 6756316. Miller SP, Karschnia EJ, Ikeda TP, LaPorte DC (1996). "Isocitrate dehydrogenase kinase/phosphatase. Kinetic characteristics of the wild-type and two mutant proteins". J. Biol. Chem. 271 (32): 19124–8. doi:10.1074/jbc.271.32.19124. PMID 8702587. Singh SK, Matsuno K, LaPorte DC, Banaszak LJ (2001). "Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase". J. Biol. Chem. 276 (28): 26154–63. doi:10.1074/jbc.M101191200. PMID 11290745. Jault JM; Cortay, JC; Blanchet, C; Laporte, DC; Di Pietro, A; Cozzone, AJ; Jault, JM (2001). "The "catalytic" triad of isocitrate dehydrogenase kinase/phosphatase from E. coli and its relationship with that found in eukaryotic protein kinases". Biochemistry. 40 (10): 3047–55. doi:10.1021/bi001713x. PMID 11258918.

Worked examples

Example 1 — a first encounter with Isocitrate dehydrogenase (NADP+) kinase

Start with the simplest possible case. Write down what Isocitrate dehydrogenase (NADP+) kinase claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In engineering, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Isocitrate dehydrogenase (NADP+) kinase before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Isocitrate dehydrogenase (NADP+) kinase ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Isocitrate dehydrogenase (NADP+) kinase

In research: Isocitrate dehydrogenase (NADP+) kinase appears in engineering research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Isocitrate dehydrogenase (NADP+) kinase in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Isocitrate dehydrogenase (NADP+) kinase is common in secondary-school and first-year university syllabi. It links to neighbouring topics EC 2.7.11, EC 2.7 stubs, Enzymes of unknown structure, so understanding it makes those chapters shorter.
In everyday life: Look for Isocitrate dehydrogenase (NADP+) kinase outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Isocitrate dehydrogenase (NADP+) kinase in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Isocitrate dehydrogenase (NADP+) kinase means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Isocitrate dehydrogenase (NADP+) kinase out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Isocitrate dehydrogenase (NADP+) kinase in simple terms?

In enzymology, a [isocitrate dehydrogenase (NADP+)] kinase (EC 2.7.11.5) is an enzyme that catalyzes the chemical reaction: ATP + [isocitrate dehydrogenase (NADP+)] ⇌ {\displaystyle \rightleftharpoons } ADP + [isocitrate dehydrogenase (NADP+)] phosphate Thus, the two substrates of this enzyme are A…

Why does Isocitrate dehydrogenase (NADP+) kinase matter?

Because it connects several engineering ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Isocitrate dehydrogenase (NADP+) kinase?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Isocitrate dehydrogenase (NADP+) kinase.