The enzyme isohexenylglutaconyl-CoA hydratase (EC 4.2.1.57) catalyzes the chemical reaction
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA ⇌ {\displaystyle \rightleftharpoons } 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]. Other names in common use include 3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase, isohexenylglutaconyl coenzyme A hydratase, β-isohexenylglutaconyl-CoA-hydratase, and 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase.
References
SEUBERT W, FASS E (1964). "Studies on the Bacterial Degradation of Isoprenoids. Iv. The Purification and Properties of Beta-Isohexenylglutaconyl-Coa-Hydratase and Beta-Hydroxy-Beta-Isohexenylglutaryl-Coa-Lyase". Biochem. Z. 341: 23–34. PMID 14339651.
