Isoliquiritigenin 2'-O-methyltransferase (EC 2.1.1.154) is an enzyme that catalyzes the chemical reaction
This is a methylation reaction in which the chalcone, isoliquiritigenin, is converted to a specific methyl ether, 2'-O-methylisoliquiritigenin. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from alfalfa. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase. Other names in common use include chalcone OMT, and CHMT.
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