Isosakuranetin, an O-methylated flavonoid, is the 4'-methoxy derivative of naringenin, a flavanone. Didymin, a disaccharide of isosakuranetin, occurs e.g. in scarlet beebalm, sweet orange, blood orange and mandarin. Isosakuranetin is a potent inhibitor of TRPM3 channels.
Biosynthesis In soybean, isosakuranetin is biosynthesised from naringenin in a methylation reaction catalysed by the enzyme flavonoid 4'-O-methyltransferase. The methyl group comes from the cofactor, S-adenosyl methionine (SAM)
Glycosides Poncirin is the 7-O-neohesperidoside of isosakuranetin. Didymin is the 7-O-rutinoside of isosakuranetin
References



