Isotocyanozene (5-cyano-isotodesnitazene) is a benzimidazole opioid analogue of isotonitazene which has been sold as a designer drug. It was first characterised by the drug checking service CanTEST, in September 2025 as an expected 'opioid' sample, and then later as an expected 'benzodiazepine' sample. Its μ-opioid in vitro activity is close to that of fentanyl. Following identification in human biological samples, isotocyanozene has been described to have opioid effects.
See also Etomethazene Isotonitazene List of benzimidazole opioids
References


