chemistry

JNJ-39393406

JNJ-39393406 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand JNJ-39393406 rather than just read about it. In short: JNJ-39393406 is an experimental medication which is under development by Janssen Pharmaceutica, a division of Johnson & Johnson, for the treatment of depressive disorders and smoking withdrawal. It acts as a selective positive allosteric modulator of the α7 nicotinic acetylcholine receptor (nAChR).

Key takeaways

JNJ-39393406 belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect JNJ-39393406 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of JNJ-39393406 from memory before moving on to harder problems.

Reference excerpt

JNJ-39393406 is an experimental medication which is under development by Janssen Pharmaceutica, a division of Johnson & Johnson, for the treatment of depressive disorders and smoking withdrawal. It acts as a selective positive allosteric modulator of the α7 nicotinic acetylcholine receptor (nAChR). It does not act on the α4β2 or α3β4 nAChRs or the serotonin 5-HT3 receptor, and does not interact with a panel of 62 other receptors and enzymes. The drug has been found to lower the agonist and nicotine threshold for activation of the α7 nAChR by 10- to 20-fold and to increase the maximum agonist response of the α7 nAChR by 17- to 20-fold. As of February 2018, JNJ-39393406 is in phase II clinical trials for both depressive disorders and smoking withdrawal. It was also under investigation for the treatment of schizophrenia and Alzheimer's disease, but development for these indications was discontinued.

See also List of investigational antidepressants List of investigational antipsychotics

References

Illustrations

Worked examples

Example 1 — a first encounter with JNJ-39393406

Start with the simplest possible case. Write down what JNJ-39393406 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to JNJ-39393406 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about JNJ-39393406 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of JNJ-39393406

In research: JNJ-39393406 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses JNJ-39393406 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: JNJ-39393406 is common in secondary-school and first-year university syllabi. It links to neighbouring topics 4-Pyridyl compounds, Amines, Benzodioxoles, so understanding it makes those chapters shorter.
In everyday life: Look for JNJ-39393406 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study JNJ-39393406 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what JNJ-39393406 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain JNJ-39393406 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is JNJ-39393406 in simple terms?

Why does JNJ-39393406 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study JNJ-39393406?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on JNJ-39393406.