chemistry

JNJ-42165279

JNJ-42165279 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand JNJ-42165279 rather than just read about it. In short: JNJ-42165279 is a drug developed by Janssen Pharmaceutica which acts as a potent and selective inhibitor of the enzyme fatty-acid amide hydrolase (FAAH), with an IC50 of 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH.

Key takeaways

JNJ-42165279 belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect JNJ-42165279 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of JNJ-42165279 from memory before moving on to harder problems.

Reference excerpt

JNJ-42165279 is a drug developed by Janssen Pharmaceutica which acts as a potent and selective inhibitor of the enzyme fatty-acid amide hydrolase (FAAH), with an IC50 of 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH. JNJ-42165279 is being developed for the treatment of anxiety disorders and major depressive disorder. Clinical development has progressed as far as Phase II human trials with two studies in patients with mood disorders registered in ClinicalTrials.gov. In early 2016, a trial with a different FAAH inhibitor — Bial's BIA 10-2474 — resulted in a series of severe adverse events, including a death. In response, Janssen announced that it was temporarily suspending dosing in its two Phase II clinical trials with JNJ-42165279, describing the decision as "precautionary measure follows safety issue with different drug in class". Janssen was emphatic that no serious adverse events had been reported in any of the clinical trials with JNJ-42165279 to date. The suspension remained in effect until more information became available about the BIA 10-2474 study. As of 2018, the trials had resumed.

See also List of investigational anxiolytics LY-2183240 URB-597 PF-3845 BIA 10-2474

References

Illustrations

Worked examples

Example 1 — a first encounter with JNJ-42165279

Start with the simplest possible case. Write down what JNJ-42165279 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to JNJ-42165279 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about JNJ-42165279 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of JNJ-42165279

In research: JNJ-42165279 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses JNJ-42165279 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: JNJ-42165279 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Benzodioxoles, Cannabinoid stubs, Cannabinoids, so understanding it makes those chapters shorter.
In everyday life: Look for JNJ-42165279 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study JNJ-42165279 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what JNJ-42165279 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain JNJ-42165279 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is JNJ-42165279 in simple terms?

Why does JNJ-42165279 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study JNJ-42165279?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on JNJ-42165279.