chemistry

Jan Hoeijmakers

Jan Hoeijmakers is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Jan Hoeijmakers rather than just read about it. In short: Jan Hendrik Jozef Hoeijmakers (born 15 March in 1951 in Sevenum) is a Dutch molecular biologist, biochemist, and molecular geneticist. Education and career Hoeijmakers studied biology from 1969 at the Radboud University Nijmegen with receiving his MSc degree in molecular biology in 1975 (with a focus on biochemistry and genetics).

Key takeaways

Jan Hoeijmakers belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Jan Hoeijmakers to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Jan Hoeijmakers from memory before moving on to harder problems.

Reference excerpt

Jan Hendrik Jozef Hoeijmakers (born 15 March in 1951 in Sevenum) is a Dutch molecular biologist, biochemist, and molecular geneticist.

Education and career Hoeijmakers studied biology from 1969 at the Radboud University Nijmegen with receiving his MSc degree in molecular biology in 1975 (with a focus on biochemistry and genetics). At the University of Amsterdam he performed his doctoral research from 1975 to 1979 and then was a lecturer at the department of microbiology from 1979 to 1981. He obtained a PhD in molecular medicine in 1981 from the University of Amsterdam under Piet Borst with dissertation Trypanosomes: Kinetoplast DNA and Antigenic Variation. At Erasmus University Rotterdam, as a member of Dirk Bootsma's group in the Institute of Genetics, Hoeijmakers was, in the department of cell biology and genetics, a senior scientist from 1981 to 1985, an associate professor from 1985 to 1993, and a professor of molecular genetics from 1993 to the present. The Royal Netherlands Academy of Arts and Sciences sponsored him as an Academy Professor from 2011 to 2016. He is the author or co-author of over 490 scientific publications. He has served on the editorial boards of five scientific journals. In 1983 he received the Harold-Quintus-Bosz Prize for his dissertation, in which he clarified the molecular mechanism of the antigen variation of trypanosomes. He uncovered the structure and main function of the network mitochondrial DNA of the parasite. He also clarified the complex genetic mechanism by which trypanosomes constantly change their surface antigens in order to escape the immune system. In Rotterdam in the early 1980s he achieved the first cloning of human genes responsible for DNA repair and discovered a strong evolutionary stability of the DNA repair system. He clarified the mechanism of nucleotide excision repair (NER) and associated hereditary diseases (xeroderma pigmentosum, Cockayne syndrome, trichothiodystrophy). He found with Jean-Marc Egly that Transcription Factor II H (TFIIH) opens the DNA for the start of the NER. Hoeijmakers was elected in 2000 a member of the Royal Netherlands Academy of Arts and Sciences (section ‘Medicine’, dept. ‘Physics’). In 2013 he was appointed a Knight in the Order of the Netherlands Lion for important research in cancer and aging. He received in 1986 the Snoo van t’Hoogerhuys Prize (for the isolation of the first human gene for DNA repair) and in 1995 the Louis-Jeantet Prize for Medicine (jointly with Dirk Bootsma for their research on DNA repair). In 1995 Hoeijmakers was elected a member of the European Molecular Biology Organization (EMBO). He received in 1998 the Spinoza Prize, the highest Dutch science award. He received in 2000 both the Van Gogh award from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) (i.e. Dutch Organization for Science) and the Descartes-Huygens award for French-Dutch scientific collaborations and in 2001 the Josephine Nefkens Prize for Cancer Research. In 2008 the European Research Council awarded him an Advanced Grant. In 2011 he received the Queen Wilhelmina Research Award from the Dutch Society for Cancer Research and, with Bert Vogelstein, the Charles Rodolphe Brupbacher Prize for Cancer Research for research on genome stability and its role in aging and cancer. In 2017 Hoeijmakers received the International Prize of the Olav Thon Foundation.

References

"Pharming Group Announces Acquisition of DNage B.V." biospace.com. March 24, 2006.

External links "Jan Hoeijmakers presents at ARDD 2021". YouTube. ARDD2021. October 26, 2021.

Illustrations

Worked examples

Example 1 — a first encounter with Jan Hoeijmakers

Start with the simplest possible case. Write down what Jan Hoeijmakers claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Jan Hoeijmakers before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Jan Hoeijmakers ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Jan Hoeijmakers

In research: Jan Hoeijmakers appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Jan Hoeijmakers in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Jan Hoeijmakers is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1951 births, Academic staff of Erasmus University Rotterdam, Biogerontologists, so understanding it makes those chapters shorter.
In everyday life: Look for Jan Hoeijmakers outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Jan Hoeijmakers in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Jan Hoeijmakers means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Jan Hoeijmakers out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Jan Hoeijmakers in simple terms?

Jan Hendrik Jozef Hoeijmakers (born 15 March in 1951 in Sevenum) is a Dutch molecular biologist, biochemist, and molecular geneticist. Education and career Hoeijmakers studied biology from 1969 at the Radboud University Nijmegen with receiving his MSc degree in molecular biology in 1975 (with a foc…

Why does Jan Hoeijmakers matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Jan Hoeijmakers?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Jan Hoeijmakers.