Joel L. Sussman (Hebrew: יואל זוסמן; born September 24, 1943) is an Israeli structural biologist best known for his studies on acetylcholinesterase, a key protein involved in transmission of nerve signals. He is Professor Emeritus of Structural Biology at the Weizmann Institute of Science in Rehovot and is Co-Director of the Israel Structural Proteomics Center.
Early life and education Sussman was born in Philadelphia, Pennsylvania and grew up in Great Neck, L.I., New York, to Ida (née Arbeit), a mathematics professor, and Harry “Pi” Sussman, an electronics engineer. He attended Great Neck North High School, where he participated in an enriched science and computing program established in the United States following the launch of Sputnik 1. As a teenager, he was active in photography and loved reading science fiction books. He earned a B.A. in mathematics and physics from Cornell University from 1961-65. In the summer of 1962, he spent 10 weeks in the Ivory Coast working and teaching young Ivorian students as part of Operation Crossroads Africa, which later served as a model for the Peace Corps. Prior to departing for Africa, he was invited to the White House as part of a group of in the program, where he met President John F. Kennedy. He then pursued doctoral studies in biophysics at the Massachusetts Institute of Technology (MIT), completing his Ph.D. in 1972 under Cyrus Levinthal. His doctoral work focused on RNA structure and advances in biological crystallography.
Academic career Sussman undertook postdoctoral research at the Hebrew University of Jerusalem (1972) with Yehuda Lapidot, and then at Duke University (1973–1976) with Sung-Hou Kim. In 1976, he immigrated to Israel with his family and joined the Weizmann Institute of Science as a senior scientist in the Department of Structural Chemistry. He was promoted to Associate Professor in 1980 and Full Professor in 1982. After his formal retirement in 2016, he remained active in research as Professor Emeritus. Sussman has also held visiting positions at several institutions in the United States, including Rutgers University, the National Cancer Institute (NIH), the Laboratory of Molecular Biology at the NIH, the Fox Chase Cancer Center, and the University of California, Berkeley.
Leadership and service At the Weizmann Institute, Sussman held multiple leadership roles:
Head, Department of Structural Chemistry (1984–1985) Head, Kimmelman Center for Biomolecular Structure and Assembly (1988–1989) Incumbent, Morton and Gladys Pickman Chair of Structural Biology (2002–2014) Director, Israel Structural Proteomics Center (2002–2014), later Co-Director From 1994 to 1999, he served as Director of the Protein Data Bank (PDB) at Brookhaven National Laboratory. He has served on numerous scientific committees in Israel and internationally, including as President of the Israel Crystallographic Society.
Research Sussman’s research spans structural biology, enzymology, and bioinformatics, with over 300 scientific publications.
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