astronomy

Johanna Joyce

Johanna Joyce is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Johanna Joyce rather than just read about it. In short: Johanna Joyce is a cancer researcher and professor at the University of Lausanne and a full Member of the Ludwig Institute for Cancer Research. Her research explores the mechanisms by which the tumour microenvironment regulates the development of cancer.

Key takeaways

Johanna Joyce belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Johanna Joyce to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Johanna Joyce from memory before moving on to harder problems.

Reference excerpt

Johanna Joyce is a cancer researcher and professor at the University of Lausanne and a full Member of the Ludwig Institute for Cancer Research. Her research explores the mechanisms by which the tumour microenvironment regulates the development of cancer. She is president of the European Association for Cancer Research, an elected fellow of the American Association for Cancer Research and an elected member of the European Molecular Biology Organisation. She has received many awards and honors including the 2020 Swiss Academy of Medical Sciences Robert Bing Prize in Neuroscience and the 2023 Pezcoller-Marina Larcher Fogazzaro-EACR Women in Cancer Research Award.

Early life and education Joyce was born in London and grew up close to Dublin. She credits her high school teachers for her inspiration to study science. She completed her undergraduate degree at Trinity College Dublin. She pursued her doctoral research at University of Cambridge, where she investigated Beckwith–Wiedemann syndrome. She subsequently went to the University of California, San Francisco for a postdoctoral fellowship with Douglas Hanahan. Joyce opened her independent research lab in 2005 at the Memorial Sloan Kettering Cancer Center as an Assistant Member.

Research and career Joyce was appointed as an assistant professor at the Weill Cornell Graduate School of Medical Sciences in 2005. At MSKCC she primarily investigated the functions of tumor-associated macrophages. She spent her time outside the lab teaching, including at City University and New York University. She was promoted to associate professor in 2010, and full professor in 2014. She moved to the University of Lausanne in 2016 where she became a professor of oncology, as well as a Member of the Ludwig Institute for Cancer Research. She later served as the inaugural executive director of the Agora Cancer Research Center in Lausanne. Joyce's research considers the tumor microenvironment and the influence of non-cancerous immune and stromal cells. Joyce combines intravital microscopy with molecular MRI to look inside the brain. She has shown that cancer cells send regulatory signals to normal tissue cells which endows them with tumor-promoting functions, and that this can enhance tumor malignancy. She uses this insight to develop new therapies that are targeted toward the tumor microenvironment. For example, her research showed that targeting macrophages that promoted cancer (tumor-associated macrophages) with an inhibitor of the CSF-1 receptor did not deplete the macrophages, but changed their function, making them cancer fighters. She looked at how tumor-associated macrophages are impacted by radiotherapy, showing this it could drive therapy resistance and trigger glioma growth. Joyce has studied the complex microenvironment of brain tumors, including functional studies of preclinical models. She has studied the role of extra-intestinal microbiota in brain metastasis, and how bacterial depletion impacts brain metastasis. Her research has revealed the phenotypes of many immune cells in the brain, and other organs, as well as endothelial and mural cells in tumour vasculature.

Awards and honours 2007 Geoffrey Beene Junior Faculty Chair 2011 Boyer Young Investigator Award 2016 Women in Science Switzerland Annual Symposium 2017 Elected Fellow of European Academy of Cancer Sciences 2017 Elected Member of the European Molecular Biology Organisation 2018 Cloëtta Prize 2020 Robert Bing Prize in Neuroscience 2022 Mark Foundation for Cancer Research ASPIRE Award 2022 Metastasis Research Society Fidler Award in Innovation 2023 Pezcoller-Marina Larcher Fogazzaro-EACR Women in Cancer Research Award 2024 Elected Academy Fellow of American Association for Cancer Research 2024 Cell Press 50 Scientists that Inspire 2024 President-Elect of European Association for Cancer Research

Selected publications Daniela F. Quail; Johanna A. Joyce (November 2013). "Microenvironmental regulation of tumor progression and metastasis". Nature medicine. 19 (11): 1423–37. doi:10.1038/nm.3394. ISSN 1078-8956. PMC 3954707. PMID 24202395. Wikidata Q29615504. Joyce JA; Pollard JW (April 2009). "Microenvironmental regulation of metastasis". Nature Reviews Cancer. 9 (4): 239–52. doi:10.1038/nrc2618. ISSN 1474-175X. PMC 3251309. PMID 19279573. Wikidata Q29547660. Stephanie M Pyonteck; Leila Akkari; Alberto J Schuhmacher; et al. (22 September 2013). "CSF-1R inhibition alters macrophage polarization and blocks glioma progression". Nature medicine. 19 (10): 1264–1272. doi:10.1038/nm.3337. ISSN 1078-8956. PMC 3840724. PMID 24056773. Wikidata Q34993852.

References

Illustrations

Worked examples

Example 1 — a first encounter with Johanna Joyce

Start with the simplest possible case. Write down what Johanna Joyce claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Johanna Joyce before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Johanna Joyce ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Johanna Joyce

In research: Johanna Joyce appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Johanna Joyce in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Johanna Joyce is common in secondary-school and first-year university syllabi. It links to neighbouring topics Academic staff of the University of Lausanne, Academics from London, Alumni of Trinity College Dublin, so understanding it makes those chapters shorter.
In everyday life: Look for Johanna Joyce outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “Johanna Joyce” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Johanna Joyce in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Johanna Joyce means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Johanna Joyce out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Johanna Joyce in simple terms?

Why does Johanna Joyce matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Johanna Joyce?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Johanna Joyce.