biology

KIAA0232

KIAA0232 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand KIAA0232 rather than just read about it. In short: KIAA0232 is a nuclear phosphoserine protein which in humans is encoded by the KIAA0232 gene. Gene KIAA0232 is located at 4p16.1 neighboring TBC1 domain family member 14 and an uncharacterized locus.

Key takeaways

KIAA0232 belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect KIAA0232 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of KIAA0232 from memory before moving on to harder problems.

Reference excerpt

KIAA0232 is a nuclear phosphoserine protein which in humans is encoded by the KIAA0232 gene.

Gene KIAA0232 is located at 4p16.1 neighboring TBC1 domain family member 14 and an uncharacterized locus. It has 10 exons which comprise its 4 known transcript variants.

Expression KIAA0232 is expressed fairly ubiquitously, but particularly highly in the brain relative to other tissues according to GEO normal tissue expression profiling. Other notable areas of high expression identified by EST profiling include nerves, umbilical cord, and parathyroid.

Homology

Paralogs There are no known paralogs of KIAA0232.

Orthologs KIAA0232 is conserved in most animals, including mammals, reptiles, birds, amphibians, insects, and as far back as Trichnella spiralis, a species of nematode. It is not found in fungi, plants, or prokaryotes.

Protein The KIAA0232 protein is 1395 amino acids in length with a molecular weight of 154.8kDa. It has higher than average frequencies of serine and glutamic acid residues as well as several multi-serine runs that are evolutionarily conserved. It has an isoelectric point of 4.52.

Domains KIAA0232 is largely composed of DUF4603.

Subcellular localization KIAA0232 is predicted to have nuclear localization.

Post-translational modification KIAA0232 is predicted by the tools at ExPASy to be highly phosphorylated, with 15 tyrosine specific sites, 25 threonine specific sites, and 103 serine specific sites.

Interacting proteins KIAA0232 is experimentally known to interact with YWHAZ, DYRK1A, and DYRK1B. via two hybrid interaction experiments. YWHAZ is an apoptotic path regulator known to bind to phosphoserine proteins. DYRK1A/B are dual-specificity tyrosine kinases. This corroborates the post-translational modification predictions.

References

Illustrations

KIAA0232: Chromosomal neighborhood of gene KIAA0232 — Chromosomal neighborhood of gene KIAA0232

Worked examples

Example 1 — a first encounter with KIAA0232

Start with the simplest possible case. Write down what KIAA0232 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to KIAA0232 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about KIAA0232 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of KIAA0232

In research: KIAA0232 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses KIAA0232 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: KIAA0232 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 4, Proteins, Uncharacterized proteins, so understanding it makes those chapters shorter.
In everyday life: Look for KIAA0232 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “KIAA0232” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study KIAA0232 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what KIAA0232 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain KIAA0232 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is KIAA0232 in simple terms?

KIAA0232 is a nuclear phosphoserine protein which in humans is encoded by the KIAA0232 gene. Gene KIAA0232 is located at 4p16.1 neighboring TBC1 domain family member 14 and an uncharacterized locus.

Why does KIAA0232 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study KIAA0232?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on KIAA0232.