biology

KIAA1143

KIAA1143 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand KIAA1143 rather than just read about it. In short: KIAA1143 is an uncharacterized protein in humans that is encoded by the KIAA1143 gene. it may play a role in cell growth mechanisms and regulation/creation of cytoskeletal structure. This gene is located on chromosome 3 on the minus strand This protein has a function that is not yet objectively understood.

Key takeaways

KIAA1143 belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect KIAA1143 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of KIAA1143 from memory before moving on to harder problems.

Reference excerpt

KIAA1143 is an uncharacterized protein in humans that is encoded by the KIAA1143 gene. it may play a role in cell growth mechanisms and regulation/creation of cytoskeletal structure. This gene is located on chromosome 3 on the minus strand This protein has a function that is not yet objectively understood. KIAA1143 has no alias and has the longest most functional variant named as uncharacterized protein KIAA1143 isoform 1. The mature mRNA transcript is 5079 Base pairs long while the length of the KIAA1143 protein is 154 amino acids. KIAA1143 has another transcript variant called KIAA1143 variant 2, which contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform 2 has a distinct C-terminus and is shorter than isoform 1. The KIAA1143 protein belongs to the uncharacterized protein KIAA1143-like Family, and contains DUF4604 domain of unknown function. KIAA1143 has a predicted function of cell structure/mobility by encoding heavy neurofilament subunits in neurons. Immunohistochemistry staining from Thermo Fisher Scientific shows presence of KIAA1143 in a cytokinetic bridge, which is involved in cellular cytokinesis. This indicates KIAA1143 may have a role in regulation of cellular division and/or communication as well.

Gene

Location KIAA1143 is found on chromosome 3 on the short arm (3p21) and has 3 exons. KIAA1143 is on the Minus Strand. KIAA1143 is on the sense strand and spans from bases 44,690,802-44,819,561. KIAA1143 is located in the gene neighborhood of Zinc finger protein 502, ZNF501, and KIF15

Transcriptional Regulation The KIAA1143 was found by using 500 bp of nucleotides upstream using UCSC Genome Browser A number of transcription factors with a matrix similarity greater than or equal to 0.5 that are predicted to regulate transcription of KIAA1143 are listed below with their respective binding site:

Expression KIAA1143 is expressed in all tissues, however, The expression of KIAA1143 is highest in the Ovaries, followed by the brain, thyroid, prostate, and urinary bladder KIAA1143 is predicted to have subcellular localization in the nucleus

mRNA

Characteristics of Isoform 1 Isoform 1 of KIAA1143 has a 5' UTR region of 17 base pairs and a 3' UTR region of 4597 base pairs. The transcript is 5079 base pairs long

Additional Primary Sequence and Variants (Isoforms) KIAA1143 has another uncharacterized isoform 2 which contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform 2 has a distinct C-terminus and is shorter than isoform 1.

Protein The theoretical molecular weight of the 154amino acid KIAA1143 protein is 17.5kDa and the theoretical pI is 5.84.

Domains, Motifs, and Secondary Structure Since KIAA1143 is an gene with unknown function, most of the coding gene apart from the promotor and translation start site area is a Domain of unknown function, specifically, DUF4604 Spans amino acids 5-151. KIAA1143 has no Cysteine or tyrosine residues. Cysteine and tyrosine are very good nucleophiles, since they are not present, this gives some light into the possible electrophilic nature of the active site. KIAA1143 has some important Eukaryotic Linear Motif resource (ELM) Domains which give insight into its function. These ELM domains are LIG_BIR_II_1 from amino acids 1-5 and LIG_WRC_WIRS_1 from amino acids 144-149. These domains have importance in apoptotic regulation and actin cytoskeleton rearrangement mechanisms respectively From Positions 1-10 there is also something called a BIG1 Big-1 (bacterial Ig-like domain 1) domain. Big-1 proteins are surface-expressed proteins that mediate mammalian host cell invasion or attachment. The tandem of Ig-like domains appears to form a rod to link the bacterial outer membrane anchor to the C-terminal lectin-like domain to interact with their receptors in the host cell membrane

Post-Translational Modifications KIAA1143 is shown to be phosphorylated at positions 2, 50, 68, 113, 115, 116 at either serine or threonine residues. There is a sumoylation consensus at position 76, as well as O-GlcNAc attachment at position 8. There is also an N-myristoylation site from 111-116

Tertiary Structures The KIAA1143 Tertiary structure is predicted below through iTASSER modeling, with a C score of -2.83. Coloring is similar to alphafold confidence graphing

Protein Interactions KIAA1143 is experimentally determined to have interactions with EAPP (E2F-associated phosphoprotein), ECD (Ecdysoneless Cell Cycle Regulator), GPATCH1 (Evolutionarily Conserved G-Patch Domain-Containing Protein), PRPF8 (Pre-MRNA-Processing-Splicing Factor 8), WDR83 (Mitogen-Activated Protein Kinase Organizer 1), CEP76 (centrosomal protein 76), and APP (Amyloid-beta precursor protein).

Homology and Evolution

Paralogs There are no paralogs for KIAA1143

Orthologs KIAA1143 has homologs in over 200 other organisms, including vertebrates, invertebrates, archaea, KIAA1143 is found in clades of organisms except land plants.

The relative rate of change for KIAA1143 is fairly slow compared to fibrinogen and beta-globin, but not as slow as cytochrome c.

Homologus Domains The DUF4604 domain in KIAA1143 is conserved across all organisms

Phylogeny All of the orthologs of KIAA1143 are derived from the same common ancestor

Clinical Significance

Pathology No diseases have been shown to be directly linked to KIAA1143 to this date.

Disease Association No Disease Association is observed with KIAA1143 to date.

References

Illustrations

Worked examples

Example 1 — a first encounter with KIAA1143

Start with the simplest possible case. Write down what KIAA1143 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to KIAA1143 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about KIAA1143 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of KIAA1143

In research: KIAA1143 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses KIAA1143 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: KIAA1143 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 3, Uncharacterized proteins, so understanding it makes those chapters shorter.
In everyday life: Look for KIAA1143 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study KIAA1143 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what KIAA1143 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain KIAA1143 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is KIAA1143 in simple terms?

Why does KIAA1143 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study KIAA1143?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on KIAA1143.