biology

KIAA1958

KIAA1958 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand KIAA1958 rather than just read about it. In short: Uncharacterized protein KIAA1958 is a protein that in humans is encoded by the KIAA1958 gene. Orthologs of KIAA1958 go as far back in evolution to chordates, although, it is closer in homology to primates than any other orthologs.

Key takeaways

KIAA1958 belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect KIAA1958 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of KIAA1958 from memory before moving on to harder problems.

Reference excerpt

Uncharacterized protein KIAA1958 is a protein that in humans is encoded by the KIAA1958 gene. Orthologs of KIAA1958 go as far back in evolution to chordates, although, it is closer in homology to primates than any other orthologs. KIAA1958 has no known paralogs.

Gene KIAA1958 is located on the long arm of chromosome 9 (9.q32) in humans on the plus strand from 115249248 to 115427597. Its mRNA has 2683 bp. The gene has these neighbors on chromosome 9:

HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in nucleotide binding, oxidoreductase activity, and sterol binding. C9orf147: Chromosome 9 open reading frame 147 has an unknown function. C9orf80: Chromosome 9 open reading frame 80 is a component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell cycle checkpoint activation, recombinational repair and maintenance of genomic stability. SNX30: Sorting nexin-30 may be linked to phosphatidylinositol binding.

Expression KIAA1958 is expressed in the highest quantities in the larynx as proposed by EST. The highest expression in developmental stage is the blastocyst and for health state, it is most found in uterine tumors. Data from NCBI GEO Profile shows that KIAA1958 expression includes many of the tissue types in the human body. Using EMBL-EBI, KIAA1958 was found to be overexpressed in pseudopod RNA during the migration of the metastatic cancer cells. KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth and viability of prostate cancer cells and both the embryonic stem cell and the pluripotent stem cell.

Protein

KIAA1958 is composed of 716 amino acids and weighs 79212 Da with an iso-electric point of 6.375. Although not much is known about the KIAA1958 protein, scientific predictions have been made using supercomputers for predictions of KIAA1958's structure and function. KIAA1958 undergoes post-translational modifications. The most interesting modification is phosphorylation. In comparison to other proteins, KIAA1958 has a substantially significant amount of serines phosphorylated during post-translational modification. 36 serines are predicted to be phosphorylated.

Structure PELE on SDSC Biology WorkBench is supercomputer that is able to predict secondary structure of the KIAA1958 protein. According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal amount and spread out almost evenly throughout the protein.

Interactions There is no known proof that KIAA1958 interacts with any other proteins at this time.

Homology

References

Illustrations

Worked examples

Example 1 — a first encounter with KIAA1958

Start with the simplest possible case. Write down what KIAA1958 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to KIAA1958 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about KIAA1958 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of KIAA1958

In research: KIAA1958 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses KIAA1958 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: KIAA1958 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 9, Uncharacterized proteins, so understanding it makes those chapters shorter.
In everyday life: Look for KIAA1958 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study KIAA1958 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what KIAA1958 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain KIAA1958 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is KIAA1958 in simple terms?

Why does KIAA1958 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study KIAA1958?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on KIAA1958.