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biology

KIDINS220

KIDINS220 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand KIDINS220 rather than just read about it. In short: Kinase D-interacting substrate of 220 kDa or ARMS (ankyrin repeat-rich membrane spanning) is a scaffold protein that in humans is encoded by the KIDINS220 gene. It is a downstream target of neuronal signaling events initiated by neutrophins and ephrins.

KIDINS220 — main illustration
KIDINS220 — illustration

Key takeaways

  • KIDINS220 belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect KIDINS220 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of KIDINS220 from memory before moving on to harder problems.

Reference excerpt

Kinase D-interacting substrate of 220 kDa or ARMS (ankyrin repeat-rich membrane spanning) is a scaffold protein that in humans is encoded by the KIDINS220 gene. It is a downstream target of neuronal signaling events initiated by neutrophins and ephrins. Additionally, it was shown to have important roles in the immune system by interacting with the B-cell and T-cell receptor.

Molecular biology The gene is located on the short arm of chromosome 2 (2p25.1) on the Crick strand. It is 116,550 bases in length. It encodes a transmembrane protein that is preferentially expressed in the nervous system. The protein acts as a receptor for the CRKL-C3G complex. Binding this complex results in Rap1-dependent sustained ERK activation. This, in turn, interacts with several pathways the effects of which are under active investigation.

Clinical importance Heterozygous mutations of this gene have been suggested as a cause of a syndrome consisting of spastic paraplegia, intellectual disability, nystagmus and obesity. Knock out mice with homozygous mutations have non-viable offspring with enlarged cerebral ventricles. A consanginous couple has been reported who suffered from repeated miscarriages in whom homozygous mutations of this gene were found. Post mortem showed enlarged cerebral ventricles and contracted limbs.

References

Further reading

Illustrations

KIDINS220 illustration
KIDINS220 illustration
KIDINS220 illustration
KIDINS220 illustration
KIDINS220 illustration

Worked examples

Example 1 — a first encounter with KIDINS220

Start with the simplest possible case. Write down what KIDINS220 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to KIDINS220 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about KIDINS220 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of KIDINS220

In research
KIDINS220 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses KIDINS220 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
KIDINS220 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Human chromosome 2 gene stubs, Human genes, so understanding it makes those chapters shorter.
In everyday life
Look for KIDINS220 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study KIDINS220 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what KIDINS220 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain KIDINS220 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is KIDINS220 in simple terms?

Kinase D-interacting substrate of 220 kDa or ARMS (ankyrin repeat-rich membrane spanning) is a scaffold protein that in humans is encoded by the KIDINS220 gene. It is a downstream target of neuronal signaling events initiated by neutrophins and ephrins.

Why does KIDINS220 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study KIDINS220?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on KIDINS220.

Tags

  • Human chromosome 2 gene stubs
  • Human genes

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