biology

KIF-binding protein

KIF-binding protein is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand KIF-binding protein rather than just read about it. In short: KIF-binding protein, also known as Kinesin binding protein (KBP), is a protein that in humans is encoded by the KIFBP gene (previously KIAA1279). The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator.

Key takeaways

KIF-binding protein belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect KIF-binding protein to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of KIF-binding protein from memory before moving on to harder problems.

Reference excerpt

KIF-binding protein, also known as Kinesin binding protein (KBP), is a protein that in humans is encoded by the KIFBP gene (previously KIAA1279). The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator. Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis. Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis, and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

Clinical significance Defects may be associated with Goldberg–Shprintzen syndrome (OMIM 609460).

Interactions KIAA1279 has been shown to interact with Retinal G protein coupled receptor and Dipeptidase 1.

References

Illustrations

Worked examples

Example 1 — a first encounter with KIF-binding protein

Start with the simplest possible case. Write down what KIF-binding protein claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to KIF-binding protein before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about KIF-binding protein ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of KIF-binding protein

In research: KIF-binding protein appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses KIF-binding protein in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: KIF-binding protein is common in secondary-school and first-year university syllabi. It links to neighbouring topics Cytoskeleton proteins, Genes on human chromosome 10, Human chromosome 10 gene stubs, so understanding it makes those chapters shorter.
In everyday life: Look for KIF-binding protein outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study KIF-binding protein in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what KIF-binding protein means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain KIF-binding protein out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is KIF-binding protein in simple terms?

Why does KIF-binding protein matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study KIF-binding protein?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on KIF-binding protein.