ArticleslgStudy

biology

KLF13

KLF13 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand KLF13 rather than just read about it. In short: Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene. There is some evidence for KLF13 having a role in obesity.

KLF13 — main illustration
KLF13 — illustration

Key takeaways

  • KLF13 belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect KLF13 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of KLF13 from memory before moving on to harder problems.

Reference excerpt

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene. There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes. Ghrelin levels also positively correlated with methylation levels of cg07814318. Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.

Function KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes. KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1. It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhanceosome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.

Interactions KLF13 has been shown to interact with CREB-binding protein, Heat shock protein 47 and PCAF.

See also Kruppel-like factors

References

Further reading

External links KLF13+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Illustrations

KLF13 illustration
KLF13 illustration
KLF13 illustration
KLF13 illustration
KLF13 illustration

Worked examples

Example 1 — a first encounter with KLF13

Start with the simplest possible case. Write down what KLF13 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to KLF13 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about KLF13 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of KLF13

In research
KLF13 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses KLF13 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
KLF13 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 15, Transcription factors, so understanding it makes those chapters shorter.
In everyday life
Look for KLF13 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study KLF13 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what KLF13 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain KLF13 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is KLF13 in simple terms?

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene. There is some evidence for KLF13 having a role in obesity.

Why does KLF13 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study KLF13?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on KLF13.

Tags

  • Genes on human chromosome 15
  • Transcription factors

Keep exploring