science

Kadmon Corporation

Kadmon Corporation is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Kadmon Corporation rather than just read about it. In short: Kadmon Corporation (originally Kadmon Pharmaceuticals) is a biopharmaceutical company based in New York City. It also has operations in Warrendale, PA and Brighton, MA.

Key takeaways

Kadmon Corporation belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Kadmon Corporation to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Kadmon Corporation from memory before moving on to harder problems.

Reference excerpt

Kadmon Corporation (originally Kadmon Pharmaceuticals) is a biopharmaceutical company based in New York City. It also has operations in Warrendale, PA and Brighton, MA. The company was founded in 2009 by Samuel D. Waksal, founder and former CEO of ImClone Systems, a company now fully merged into Eli Lilly. Waksal had served a federal prison sentence stemming from his fiduciary role as CEO in the 2001 ImClone stock trading case. When released in 2009 he was barred from serving as an officer for any publicly traded company but Kadmon was privately financed. In September 2014, amid plans to take the company to an IPO Harlan W. Waksal, brother of Samuel Waksal, became President and Chief Executive Officer while Samuel Waksal remained on with the title Chief of Innovation, Science and Strategy. In early 2016 Sam Waksal left Kadmon and in June the company filed paperwork for its IPO. On July 27, 2016 the company's stock began trading on the NYSE under the symbol KDMN but switched to NASDAQ in October 2020. On 8 September 2021, Sanofi announced it would acquire the company for $1.9 billion. The deal completed in November and its stock was deregistered as it became a subsidiary of Sanofi. As of 2019 Kadmon had ongoing clinical trials for Belumosudil in specific fibrotic and neurodegenerative diseases and tesevatinib to treat autosomal dominant polycystic kidney disease (PKD) and autosomal recessive PKD.

Product acquisitions During Waksal's leadership of ImClone the company was engaged in early stage research projects for 15 years before filing its first drug application. Kadmon however immediately began acquiring drugs further advanced - either already marketed in the US or in the later stages of clinical development. It acquired the Warrendale, PA-based company Three Rivers Pharmaceuticals and their Ribasphere and topotecan products. It also signed an agreement with Ontario, Canada-based Valeant Pharmaceuticals for their Hepatitis C drugs ribavirin and taribavirin (now KD024). Cancer drugs XL647 and XL844 were acquired from Exelixis. An inhibitor of several protein kinases, tesevatinib (XL647, KD019) entered Phase II clinical trial for certain indications of non-small cell lung cancer. and in polycystic kidney disease. XL844 is an inhibitor of protein kinases Chk1 and Chk2 and may increase the sensitivity of cancer cells to radiation therapy. In an acquisition atypical for a biotechnology company, an 1800-year-old Chinese herbal formula was added to Kadmon's portfolio. PhytoCeutica's PHY906 (KD018) is a formula of four botanical products that had long been used for the treatment of gastrointestinal distress. Preclinical studies have shown it to enhance the therapeutic activity of several anticancer agents. In 2014 KD018 was in a Phase II trial in combination with irinotecan in metastatic colon cancer. In 2011 the company acquired rights from Brighton, MA-based Nano Terra Inc. for their Pharmacomer Technology research platform and three drug candidates in clinical development. These compounds include SLx-2119 (KD025), an inhibitor to Rho kinase 2 (ROCK2) with possible potential in fibrotic disease and focal cerebral ischemia. SLx-4090 (KD026) is a triglyceride transfer protein (MTP) inhibitor being explored for metabolic disorders. SLx-2101 (KD027) is a phosphodiesterase 5 (PDE5) inhibitor, a class of drug used in the treatment of erectile dysfunction. In 2012 the rights to salirasib (KD032), a Ras antagonist in development for cancer therapy, were acquired from Concordia Pharmaceuticals of Fort Lauderdale, FL. It also acquired the rights from Burlington, MA-based Dyax Corp. for DX-2400, a Matrix metalloproteinase-14 (MPP-14) targeted monoclonal antibody intended to inhibit tumor blood vessel formation and metastasis.

Products As of 2019 Kadmon produces several generic drugs approved by the Food and Drug Administration in the United States.

Capecitabine tablets, a nucleoside metabolic inhibitor for the treatment of colon and breast cancer Dofetilide capsules, a cardiac antiarrhythmic drug. Entecavir tablets, a virus nucleoside analog reverse transcriptase inhibitor indicated for the treatment of chronic hepatitis B virus infection. Ribavirin for the treatment of chronic hepatitis C Temozolomide capsules, an alkylating drug for the treatment of glioblastoma multiforme and astrocytoma. Tetrabenazine tablets, a vesicular monoamine transporter 2 inhibitor indicated for the treatment of Huntington's disease. Tobramycin, as an inhalation nebulizer solution for the treatment of cyctic fibrosis.

References

External links Official website

Worked examples

Example 1 — a first encounter with Kadmon Corporation

Start with the simplest possible case. Write down what Kadmon Corporation claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Kadmon Corporation before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Kadmon Corporation ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Kadmon Corporation

In research: Kadmon Corporation appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Kadmon Corporation in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Kadmon Corporation is common in secondary-school and first-year university syllabi. It links to neighbouring topics 2009 establishments in New York City, 2021 mergers and acquisitions, American companies established in 2009, so understanding it makes those chapters shorter.
In everyday life: Look for Kadmon Corporation outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Kadmon Corporation in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Kadmon Corporation means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Kadmon Corporation out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Kadmon Corporation in simple terms?

Kadmon Corporation (originally Kadmon Pharmaceuticals) is a biopharmaceutical company based in New York City. It also has operations in Warrendale, PA and Brighton, MA.

Why does Kadmon Corporation matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Kadmon Corporation?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Kadmon Corporation.