chemistry

Ketamir-2

Ketamir-2 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Ketamir-2 rather than just read about it. In short: Ketamir-2, or simply Ketamir, also known as oral ketamine analogue or as 1-(2-chlorophenyl)-N-methyl-2-oxocyclopentan-1-amine, is an NMDA receptor antagonist closely related ketamine and other arylcyclohexylamines which is under development for the treatment of depressive disorders and other conditions such as neuropathic pain. It is the analogue of ketamine in which the 6-membered cyclohexane ring has been replaced…

Key takeaways

Ketamir-2 belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Ketamir-2 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Ketamir-2 from memory before moving on to harder problems.

Reference excerpt

Ketamir-2, or simply Ketamir, also known as oral ketamine analogue or as 1-(2-chlorophenyl)-N-methyl-2-oxocyclopentan-1-amine, is an NMDA receptor antagonist closely related ketamine and other arylcyclohexylamines which is under development for the treatment of depressive disorders and other conditions such as neuropathic pain. It is the analogue of ketamine in which the 6-membered cyclohexane ring has been replaced with a 5-membered cyclopentane ring. Ketamir-2 is orally active.

Pharmacology Ketamir-2 is a very low-affinity antagonist of the phencyclidine (PCP) site of the NMDA receptor. Its affinity (IC50Tooltip half-maximal inhibitory concentration) for the PCP site of the NMDA receptor is approximately 100 μM, whereas that of ketamine (Ki) has been found to be about 660 nM (which is ~150-fold higher affinity). Ketamir-2 also has a major active metabolite, desmethylketamir (norketamir), which has an affinity (IC50) for the PCP site of the NMDA receptor of about 470 μM. Ketamir-2 showed no activity at other sites besides the PCP site of the NMDA receptor when screened against a panel of 40 receptors, transporters, enzymes, and ion channels. This is in contrast to ketamine, which shows appreciable affinities for a variety of other targets. As such, Ketamir-2 is claimed to be more selective than ketamine. Whereas ketamine is a substrate for P-glycoprotein and this might impede its absorption and distribution, Ketamir-2 does not bind to this protein. Relatedly, Ketamir-2 shows improved oral bioavailability relative to ketamine and might have better blood–brain barrier permeability. Ketamir-2 displays a pharmacokinetic profile in animals of rapid absorption and short elimination half-life. Whereas ketamine produces hyperlocomotion in rodents, a stimulant- and putatively psychotic-like effect, Ketamir-2, depending on the dose, either did not affect locomotor activity or decreased it. Ketamir-2 showed antidepressant-like, anxiolytic-like, and analgesic-like effects in animal models.

History Ketamir-2 is under development by MIRA Pharmaceuticals. As of July 2024, it is in the preclinical research stage of development. In June 2025, the first journal article about Ketamir-2 was published. According to the Drug Enforcement Administration (DEA), Ketamir-2 is not a controlled substance in the United States as of 2024.

See also List of investigational hallucinogens and entactogens Arylcyclohexylamine § Related compounds PCPEP

References

External links Ketamir-2 (Ketamir) - Isomer Design Ketamir - MIRA Pharmaceuticals

Illustrations

Worked examples

Example 1 — a first encounter with Ketamir-2

Start with the simplest possible case. Write down what Ketamir-2 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Ketamir-2 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Ketamir-2 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Ketamir-2

In research: Ketamir-2 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Ketamir-2 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Ketamir-2 is common in secondary-school and first-year university syllabi. It links to neighbouring topics 2-Chlorophenyl compounds, Cyclic ketones, Cyclopentanes, so understanding it makes those chapters shorter.
In everyday life: Look for Ketamir-2 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Ketamir-2 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Ketamir-2 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Ketamir-2 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Ketamir-2 in simple terms?

Why does Ketamir-2 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Ketamir-2?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Ketamir-2.