Kinesia paradoxa is a phenomenon most often seen in people with Parkinson's disease where individuals who typically experience severe difficulties with the simple movements may perform complex movements easily. Specifically, kinesia paradoxa focuses on walking, referring to the sudden ability to demonstrate smooth, fluid movements in people that previously had problems with walking easily. This new discovery does not just happen to an individual randomly, but must be stimulated using various types of visual or auditory cues. This phenomenon is generally stimulated to help improve the mobility of people with akinesia. Akinesia consists of changes in walking pattern, freezing of gait (FOG), and losses of balance (LOBs). FOG occurs in the middle of stride, cutting off walking, and making it fairly difficult for a person to re-initiate a movement. Kinesia paradoxa can be used as a management strategy to overcome this. LOBs are when a person has difficulty maintaining an upright position and lose their balance, eventually leading to them falling. Since Parkinson’s disease is a progressive disease, patient’s symptoms continue to worsen with time and they often develop visible differences in their walking that greatly affects their quality of life. These differences include shuffling of steps, decreased stride length, and decrease in overall movement. Kinesia paradoxa is not able to be stimulated in everyone with movement disorders; persons who can stimulate this phenomenon demonstrate visible improvements in mobility including, increased stride length, more fluidity in strides, less FOGs incidents, less LOBs, and those that appeared to be completely frozen previously can regain their movement. More recently, kinesia paradoxa is also being used to treat children with Asperger's syndrome. Children with Asperger's demonstrate excellent skills in drawing, modeling, building, and computer games, but often struggle with everyday motor tasks such as walking or catching a ball. Kinesia paradoxa is currently being explored to help aid these individuals in focusing their attention and improving their efficiency in these simple motor tasks.
History One of the first studies on kinesia paradoxa was conducted in 1967 by James Martin. He examined the effects of different visual cues to facilitate natural walking and found that transverse lines that were one or two inches wide and a contrasting color produced the maximum effect. He studied the effects from different obstacles, types of lines, different contrasts, and how outside stimuli affected kinesia paradoxa. Since this primary study, more progress has been made to explore this topic and methods to stimulate it. It is still fairly new in the research field and there is much more future research to be conducted before this topic can be fully understood.
Mechanism of action There is currently no known mechanism to explain kinesia paradoxa, but it is believed to be a normal property of the motor system. The reasoning behind the sudden movement is still very unclear and a variable topic of research that has not yet been studied electrophysiologically. There are a few hypotheses that are currently being studied which include: Additional feedback to the brain Individuals with Parkinson's have a lack of dopaminergic cells which results in the difficulty with movement. Providing additional feedback to the brain can help overcome the problems individuals have with internal cueing. Circuits in the brain Visual cues are believed to activate specific motor pathways in the brain. These pathways allow the damaged circuits from Parkinson's to be bypassed, resulting in normal motor function. Cerebellar sensory-motor pathway are currently being explored to try and prove this hypothesis. Part of the initiation, not the pathway If the circuits in the brain do not play a role in stimulating kinesia paradoxa, the initiation of this stimulation should be explored to be a possible explanation. Additional firing within the brain could be a possible explanation to these improved movements. Possible genotype A possible genotype might make an individual more likely to be able to stimulate kinesia paradoxa, but currently there is no current research on this idea. It is difficult to support this idea with scientific research.
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