Kynurenine-glyoxylate transaminase (EC 2.6.1.63) is an enzyme that catalyzes the overall chemical reaction:
The two substrates of this enzyme characterised from liver are L-kynurenine and glyoxylic acid. The amino group from the amino acid of kynurenine is transferred, forming glycine and an intermediate α-keto acid, which spontaneously loses water to give kynurenic acid as the stable product. The enzyme accepts other substrates, including alanine and 3-hydroxykynurenine. It is found in Aedes aegypti and Anopheles gambiae. This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-kynurenine:glyoxylate aminotransferase (cyclizing). This enzyme is also called kynurenine-glyoxylate aminotransferase.
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