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LOC101928193

LOC101928193 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand LOC101928193 rather than just read about it. In short: LOC101928193 is a protein which in humans is encoded by the LOC101928193 gene. There are no known aliases for this gene or protein.

LOC101928193 — main illustration
LOC101928193 — illustration

Key takeaways

  • LOC101928193 belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect LOC101928193 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of LOC101928193 from memory before moving on to harder problems.

Reference excerpt

LOC101928193 is a protein which in humans is encoded by the LOC101928193 gene. There are no known aliases for this gene or protein. Similar copies of this gene, called orthologs, are known to exist in several different species across mammals, amphibians, fish, mollusks, cnidarians, fungi, and bacteria. The human LOC101928193 gene is located on the long (q) arm of chromosome 9 with a cytogenic location at 9q34.2. The molecular location of the gene is from base pair 133,189,767 to base pair 133,192,979 on chromosome 9 for an mRNA length of 3213 nucleotides. The gene and protein are not yet well understood by the scientific community, but there is data on its genetic makeup and expression. The LOC101928193 protein is targeted for the cytoplasm and has the highest level of expression in the thyroid, ovary, skin, and testes in humans.

Gene

Locus The cytogenic location of LOC101928193 in humans is located on the positive strand at 9q34.2. The molecular location of the protein-encoding region of LOC101928193 is from base pairs 133,189,767 to 133,192,979. Within this region, there is 1 intron and 2 exons.

Gene neighborhood LOC101928193 is flanked by GBGT1 and 0BP2B on chromosome 9. GBGT1 encodes a member of the ABO gene family and also plays a role in synthesizing glycolipids that are involved in tropism and binding pathogens. 0BP2B is a gene that associates with E-Selectin Level in the ABO gene region.

mRNA In humans, the LOC101928193 gene produces 3 transcript variants, which produce 3 isoforms of the protein. The LOC101928193 isoform X1 is the longest one at 406 codons in length. LOC101928193 isoform X2 is 388 codons long and LOC101928193 isoform X3 is 399 codons long. All isoforms have 2 exons and their coding mRNA is 3213 nucleotides long.

Protein The molecular weight of LOC101928193 is 43.5 kilodaltons. The isoelectric point is 9 pI.

Composition Compared to most human proteins, there are more valine, glycine, serine, histidine, and phenylalanine residues in LOC101928193. LOC101928193 is an alanine, methionine, asparagine, aspartic acid, glutamic acid, and lysine poor protein. The enrichment of all other amino acids is normal compared to other human proteins. LOC101928193 composition is highly conserved between mammals.

LOC101928193 has an amino acid charge distribution of 0.7% negative, 4.9% positive, and 94.4% neutral. There are no charge runs, hydrophobic segments, or transmembrane domains.

Domains and motifs There are two different motifs present in LOC101928193. Myristoylation sites are found in the protein sequence 17 times, and a zinc finger domain motif occurs once. The presence of myristoylation sites indicates that LOC101928193 may function in membrane targeting, protein-protein interactions, and signal transduction pathways. Zinc finger domain motifs aid in gene transcription, cell adhesion, protein folding, and chromatin remodeling.

Primary sequence The LOC101928193 primary coding sequence mRNA is 3213 nucleotides long. There are no upstream open-reading frames, Kozak consensus sequences, or transmembrane regions.

Secondary structure LOC101928193 has a predicted secondary structure of 56.40% random coils and 43.60% beta sheets. No alpha helices are predicted to occur. Due to the lack of alpha helices in the protein, no coiled coils are predicted to occur in the LOC101928193 secondary structure.

Tertiary structure The tertiary structure of LOC101928193 is an all beta-sheet protein, as can be seen by its predicted tertiary structure. Both the N-terminus and the C-terminus lack beta-sheets.

Post-translational modifications

O-GlcNAc There are 13 predicted O-GlcNAc sites within the LOC101928193 protein. O-GlcNAc is a unique form of protein glycosylation that occurs exclusively in the nuclear and cytoplasmic compartments of the cell. O-Glc-NAcylated proteins are abundant on proteins involved in signaling pathways, stress responses, cytoskeletal assembly, and energy metabolism.

N-linked glycosylation There are no N-linked glycosylation sites due to the absence of asparagine residues.

Phosphorylation LOC101928193 has many sites of phosphorylation at several serines, threonines, and tyrosines throughout its structure that results in a conformational change and aids in signaling pathways and regulation. There are 33 predicted phosphorylation sites. The relative amount of phosphorylation sites is highly conserved throughout orthologs of LOC101928193.

Subcellular localization LOC101928193 is targeted to the cytoplasm for Homo sapiens, rodents, amphibians, fish, and mollusks. It is predicted to localize in the nucleus for cnidarians, fungi, and bacteria.

Expression LOC101928193 is not expressed ubiquitously, but is instead tissue specific in low levels of mRNA abundance compared to other human proteins. LOC101928193 has the highest level of expression in the thyroid and has high levels of expression in the ovaries, skin, and testes. Additionally, the gene is expressed in 23 other tissues at levels lower than 0.1 RPKM (Reads Per Kilobase of transcript per Million mapped reads) in humans. Other studies have also found that tissue-specific circular RNA induction of LOC101928193 during human fetal development has the highest levels in the heart, kidney, and stomach at 10 weeks gestational time.

Regulation of Expression

Epigenetic Epigenetic processes such as DNA methylation and histone modification that control expression have not been found in LOC101928193.

Transcriptional

Promoter There is one promoter for the LOC101928193 gene (GXP_6058323), and it is 1101 nucleotides long on the positive strand from base pairs 133,188,767 to 133,189,867 on chromosome 9. The transcription start site can be found at the 1001 base pair position.

Transcription factor binding sites Several transcription factors are predicted to bind to the promoter sequence. Some examples include:

X-box binding factors Nuclear factor kappa B/c-rel MAF and AP1 related factors Interferon regulatory factors RBPJ-kappa MEF3 binding sites Cart-1 homeoprotein Fork head domain factors Based on the functions of these transcription factors, it is possible that LOC101928193 may have been involved in gene repression, hematopoiesis regulation, fetal development, inhibition, DNA-binding, or limb development.

… excerpt ends here. Continue reading the full article.

Illustrations

LOC101928193: LOC101928193 amino acid composition.[12] This is a glycine, valine, and serine rich protein. It is also methionine, asparagine, aspartic acid, glutamic acid, and lysine poor.
LOC101928193 amino acid composition.[12] This is a glycine, valine, and serine rich protein. It is also methionine, asparagine, aspartic acid, glutamic acid, and lysine poor.
LOC101928193: LOC101928193 predicted secondary structure.[13] The orange c's indicate predicted coils and the red e's indicate predicted beta sheets.
LOC101928193 predicted secondary structure.[13] The orange c's indicate predicted coils and the red e's indicate predicted beta sheets.
LOC101928193: LOC101928193 predicted tertiary structure. Image coloured by rainbow N → C terminus.[14]
LOC101928193 predicted tertiary structure. Image coloured by rainbow N → C terminus.[14]
LOC101928193: LOC101928193 conceptual translation with post-translational modifications and motifs.
LOC101928193 conceptual translation with post-translational modifications and motifs.
LOC101928193: The Mean RPKM Values of 27 Different Human Tissues From RNA-Sequencing of LOC101928193.[4] The protein is most highly expressed in the thyroid, ovaries, skin, and testes.
The Mean RPKM Values of 27 Different Human Tissues From RNA-Sequencing of LOC101928193.[4] The protein is most highly expressed in the thyroid, ovaries, skin, and testes.

Worked examples

Example 1 — a first encounter with LOC101928193

Start with the simplest possible case. Write down what LOC101928193 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to LOC101928193 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about LOC101928193 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of LOC101928193

In research
LOC101928193 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses LOC101928193 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
LOC101928193 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 9, Human genes, Proteins, so understanding it makes those chapters shorter.
In everyday life
Look for LOC101928193 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study LOC101928193 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what LOC101928193 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain LOC101928193 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is LOC101928193 in simple terms?

LOC101928193 is a protein which in humans is encoded by the LOC101928193 gene. There are no known aliases for this gene or protein.

Why does LOC101928193 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study LOC101928193?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on LOC101928193.

Tags

  • Genes on human chromosome 9
  • Human genes
  • Proteins

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