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LRRC24

LRRC24 is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand LRRC24 rather than just read about it. In short: Leucine rich repeat containing 24 is a protein that, in humans, is encoded by the LRRC24 gene. The protein is represented by the official symbol LRRC24, and is alternatively known as LRRC14OS.

LRRC24 — main illustration
LRRC24 — illustration

Key takeaways

  • LRRC24 belongs to biology; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect LRRC24 to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of LRRC24 from memory before moving on to harder problems.

Reference excerpt

Leucine rich repeat containing 24 is a protein that, in humans, is encoded by the LRRC24 gene. The protein is represented by the official symbol LRRC24, and is alternatively known as LRRC14OS. The function of LRRC24 is currently unknown. It is a member of the leucine-rich repeat (LRR) superfamily of proteins.

Gene In humans, LRRC24 is located on Chromosome 8 (8q24.3). The gene spans approximately 4.66 kb on the opposite strand. LRRC24 is composed of five exons, and only a single gene isoform has been identified.

Protein

General features LRRC24 is a transmembrane protein of unknown function. Human LRRC24 consists of 513 amino acids including a 23 amino acid signal peptide. The mature form of the protein has a molecular weight of 52.9 kDa. The isoelectric point of the mature human protein is 7.98 The protein is largely composed of alpha helices.

Domains LRRC24 is a single-pass transmembrane protein. The protein consists of six leucine-rich repeats and an immunoglobulin-like domain.

Localization LRRC24 is a secreted protein as is evidenced by the presence of a signal peptide. The structure of the protein suggests that it localizes to the cell membrane.

Homology LRRC24 is conserved in Euteleostomi with the exception of Aves. Also, based on sequence homology analysis, distant orthologs of LRRC24 are also conserved in invertebrates of phyla Mollusca and Arthropoda. No human paralogs of LRRC24 have been identified.

Expression Microarray and in situ hybridization experiments suggest LRRC24 is primarily expressed within the brain. Expression is observed to be especially high within the midbrain, neocortex, and tissues of the limbic system, including the hypothalamus and hippocampal formation.

Interactions Protein-protein interactions of LRRC24 implicate the protein with cell signaling, cell migration, and axon guidance. ROBO2 was found to interact with LRRC24. ROBO2 is a member of the Roundabout gene family, which are well known to play a significant role in nervous system development. Also, LRRC24 was found to interact with LRRTM4, a protein believed to be involved in synaptogenesis, as well as the maintenance of the nervous system in vertebrates. LRRC24 has also been found to interact with IGFBP7, a known regulator of insulin-like growth factors (IGFs). IGFBP7 is also involved in the stimulation of cell adhesion.

Clinical significance To date, no study has specifically implicated LRRC24 or the LRRC24 gene with any case of clinical significance.

References

Illustrations

LRRC24 illustration
LRRC24 illustration
LRRC24 illustration
LRRC24 illustration
LRRC24: An unrooted phylogenetic tree of LRRC24 orthologs generated using Phylip’s DrawTree[16] and ClustalW.[9][19]
An unrooted phylogenetic tree of LRRC24 orthologs generated using Phylip’s DrawTree[16] and ClustalW.[9][19]

Worked examples

Example 1 — a first encounter with LRRC24

Start with the simplest possible case. Write down what LRRC24 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to LRRC24 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about LRRC24 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of LRRC24

In research
LRRC24 appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses LRRC24 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
LRRC24 is common in secondary-school and first-year university syllabi. It links to neighbouring topics Genes on human chromosome 8, Membrane proteins, so understanding it makes those chapters shorter.
In everyday life
Look for LRRC24 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study LRRC24 in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what LRRC24 means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain LRRC24 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is LRRC24 in simple terms?

Leucine rich repeat containing 24 is a protein that, in humans, is encoded by the LRRC24 gene. The protein is represented by the official symbol LRRC24, and is alternatively known as LRRC14OS.

Why does LRRC24 matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study LRRC24?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on LRRC24.

Tags

  • Genes on human chromosome 8
  • Membrane proteins

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