LY-266097 is a synthetic β-carboline which acts as a potent and selective antagonist for the 5-HT2B receptor, with more than 100x selectivity over the related 5-HT2A and 5-HT2C receptor subtypes. However, other sources have stated that LY-266097 is actually a biased agonist of the receptor, selective for Gq signaling but not β-arrestin2. The drug has been used to study the role of the 5-HT2B receptor in modulating dopamine release in the brain, as well as its involvement in other processes such as allodynia.
See also Substituted β-carboline Fenharmane LY-272015 1-(2,4,5-Trimethoxyphenyl)-6-chlorotryptoline
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