LY-293284, also known as 4,α-methylene-5-acetyl-DPT, is a research chemical developed by the pharmaceutical company Eli Lilly and used for scientific studies. It acts as a potent and selective 5-HT1A receptor full agonist (Ki = 0.088 nM; EC50Tooltip half-maximal effective concentration = 0.13 nM). It was derived through structural simplification of the ergoline based psychedelic LSD, but is far more selective for 5-HT1A with over 1,000-fold selectivity over other serotonin receptor subtypes and other targets. It has anxiogenic effects in animal studies. In addition, it does not substitute for LSD in rodent drug discrimination tests.
See also Partial lysergamide LY-301317 LY-178210 8-OH-DPAT RDS-127 RU-27849 RU-28306 N-DEAOP-NMT CT-5252
References
External links LY-293284 - Isomer Design


