astronomy

Leonard H. Rome

Leonard H. Rome is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Leonard H. Rome rather than just read about it. In short: Leonard H. Rome is a cell biologist and biochemist who has been a faculty member of the David Geffen School of Medicine at UCLA, since he joined the Department of Biological Chemistry there, in 1979.

Key takeaways

Leonard H. Rome belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Leonard H. Rome to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Leonard H. Rome from memory before moving on to harder problems.

Reference excerpt

Leonard H. Rome is a cell biologist and biochemist who has been a faculty member of the David Geffen School of Medicine at UCLA, since he joined the Department of Biological Chemistry there, in 1979. He became a full professor in 1988 and has also served as the Senior Associate Dean for Research in the Geffen School of Medicine from 1997 to 2012. He is the Associate Director of the California NanoSystems Institute (CNSI) since 2004, and was Interim Director from 2007-2009. In addition, he served from 2001 to 2005 as University of California, Los Angeles (UCLA) Associate Vice Chancellor for Research for the Life and Health Sciences. Rome earned his B.S. in chemistry and M.S. and Ph.D. in biochemistry (biological chemistry) at the University of Michigan Health System with William E.M. Lands. He was a postdoctoral fellow at the National Institutes of Health, where he worked with Elizabeth F. Neufeld on lysosome biogenesis and lysosomal storage diseases. His laboratory research at UCLA centers on a novel cellular organelle called a vault which he and a former postdoc, Nancy Kedersha, discovered in 1986. Rome is the past chair of the Association of American Medical Colleges (AAMC) Group on Research Advancement and Development (GRAND).

Research Rome’s lab is using molecular engineering of a naturally occurring cellular structure called a vault to develop a flexible, targetable nanoscale capsule. Vaults are abundant cellular particles of unknown function found in nearly all eukaryotes (cells containing a nucleus). In 1986, Rome and his then postdoctoral associate Nancy Kedersha were the first investigators to isolate and describe the vault particle. Cryo-electron microscopy, plus single particle reconstruction, has provided overall dimensions of the vault at 42 x 75 nanometers (a nanometer is a billionth of a meter). These measurements indicate that the vault is larger in mass and size than many viruses. The overall structure of the intact vault is like a hollow barrel with two protruding caps and an indented waist with a very thin shell surrounding an internal cavity large enough to encompass several hundred proteins. Thus, the vault particle is a nanocapsule with high potential to encapsulate, protect, and deliver compounds. Using a well-characterized insect virus into which a cloned gene can be easily inserted, it is possible to produce large amounts of a given protein in cultured insect cells. The Rome lab has collaborated with several groups to use the baculovirus system to produce large amounts of vaults. When the major vault protein (MVP) is expressed in insect cells, vault particles are assembled on polysomes (polyribosomes) in the cytoplasm. By using molecular genetic methods to modify the gene encoding the major vault protein, vault particles have been produced with chemically active peptides attached to their sequence. These modified proteins are incorporated into the inside of the vault particle without altering its basic structure. In 2003, Rome cofounded a company called Vault Pharma Inc., to move the first vault therapeutic into a phase I clinical trial. This vault is packaged with a chemokine and will be used to activate the immune system to attack lung cancer. As of 2012, Vault Pharma is working with Protein Sciences Corp., to develop the GLP/cGMP manufacture of this vault-based therapeutic.

References

External links Official website, at UCLA Official website, Vault Pharma, Inc. CNSI profile

Worked examples

Example 1 — a first encounter with Leonard H. Rome

Start with the simplest possible case. Write down what Leonard H. Rome claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Leonard H. Rome before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Leonard H. Rome ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Leonard H. Rome

In research: Leonard H. Rome appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Leonard H. Rome in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Leonard H. Rome is common in secondary-school and first-year university syllabi. It links to neighbouring topics Living people, Nanotechnologists, University of Michigan alumni, so understanding it makes those chapters shorter.
In everyday life: Look for Leonard H. Rome outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “Leonard H. Rome” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Leonard H. Rome in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Leonard H. Rome means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Leonard H. Rome out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Leonard H. Rome in simple terms?

Leonard H. Rome is a cell biologist and biochemist who has been a faculty member of the David Geffen School of Medicine at UCLA, since he joined the Department of Biological Chemistry there, in 1979.

Why does Leonard H. Rome matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Leonard H. Rome?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Leonard H. Rome.