Lergotrile (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code name LY-79907) is an ergoline derivative which acts as a dopamine receptor agonist. It was developed for the treatment of Parkinson's disease, but failed in clinical trials due to liver toxicity. The drug's hydroxylated metabolite 13-hydroxylergotrile is 100-fold more potent as a dopamine receptor agonist than lergotrile itself in vitro.
See also Substituted ergoline Delergotrile
References



