astronomy

Lewis B. Sheiner

Lewis B. Sheiner is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Lewis B. Sheiner rather than just read about it. In short: Lewis B. Sheiner (1940 – April 22, 2004) was an American pharmacologist, known for his seminal work developing and applying mathematical models to problems in pharmacodynamics and pharmacokinetics.

Key takeaways

Lewis B. Sheiner belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Lewis B. Sheiner to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Lewis B. Sheiner from memory before moving on to harder problems.

Reference excerpt

Lewis B. Sheiner (1940 – April 22, 2004) was an American pharmacologist, known for his seminal work developing and applying mathematical models to problems in pharmacodynamics and pharmacokinetics.

Early life and education Born in New York City in 1940, Lewis B. Sheiner received his Bachelor of Arts degree with Honors in Chemistry from Cornell University in 1960 and earned his Doctor of Medicine (M.D.) from the Albert Einstein College of Medicine in 1964.

Career After earning his M.D., Sheiner did a three-year stint at Columbia Presbyterian Medical Center, first as an intern and then as a resident. He then served as a Research Associate at the National Institutes of Mental Health and the NIH Division of Computer Research and Technology. Sheiner completed his medical residency training at Stanford University in 1970. A two-year Clinical Pharmacology Fellowship at the University of California, San Francisco (UCSF) lead to a faculty position starting in 1972. He remained at UCSF for the remainder of his career, where hist last title was Professor of Laboratory Medicine, Medicine and Biopharmaceutical Sciences.

Research and contributions Sheiner's research focused on developing mathematical models and data analysis techniques to quantitatively characterize the impact of drug therapy from observational data, gathered either during drug development trials or during routine patient care. The practical objective motivating his research was more efficient and informative clinical trials as well as the ability to optimize dosage recommendations for individual patients. His work has influenced clinical pharmacology as a scientific discipline as well as the pharmaceutical industry and drug regulation more broadly. Sheiner's models have been implemented via software such as NONMEM, co-developed with Barr Rosenberg. Among his many notable papers are "Modelling of individual pharmacokinetics for computer-aided drug dosage" in 1972, "Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models" co-written with Nick Holford in 1981, and "Learning versus confirming in clinical drug development" in 1997.

Awards and honors Sheiner received the Oscar B. Hunter Award, the highest honor of the American Society for Clinical Pharmacology and Therapeutics (ASCPT), in 2004. He was given an Honorary Doctorate from Uppsala University, Sweden in 1995 and received the Rawls Palmer Progress in Medicine Award of the ASCPT in 1989. Posthumously, several awards have been named in Sheiner's honor, including the International Society of Pharmacometrics (ISoP) Lewis B. Sheiner Lecturer Award and the ASCPT's Sheiner-Beal Pharmacometrics Award.

Death Sheiner died on April 22, 2004, at the age of 63, after experiencing cardiac arrhythmias while traveling by train from a scientific workshop in Sils Maria, Switzerland.

References

Worked examples

Example 1 — a first encounter with Lewis B. Sheiner

Start with the simplest possible case. Write down what Lewis B. Sheiner claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Lewis B. Sheiner before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Lewis B. Sheiner ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Lewis B. Sheiner

In research: Lewis B. Sheiner appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Lewis B. Sheiner in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Lewis B. Sheiner is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1940 births, 2004 deaths, Albert Einstein College of Medicine alumni, so understanding it makes those chapters shorter.
In everyday life: Look for Lewis B. Sheiner outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “Lewis B. Sheiner” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Lewis B. Sheiner in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Lewis B. Sheiner means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Lewis B. Sheiner out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Lewis B. Sheiner in simple terms?

Lewis B. Sheiner (1940 – April 22, 2004) was an American pharmacologist, known for his seminal work developing and applying mathematical models to problems in pharmacodynamics and pharmacokinetics.

Why does Lewis B. Sheiner matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Lewis B. Sheiner?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Lewis B. Sheiner.