A limbal nodule is any nodular lesion at the limbus (junction of the cornea and sclera) of the eye. The differential diagnosis for a limbal nodule can include:
Pinguecula Early Pterygium Foreign body / foreign body granuloma Phlycten, an inflamed nodule of lymphoid tissue Episcleritis Scleritis Granuloma Limbal dermoid, a kind of choristoma (NB: in other organs dermoid can refer to a teratoma) malignant melanoma naevus A 1989 case series of 636 limbal nodules examined over a period of 40 years at the Institute of Ophthalmology in London reported that 351 nodules involved malanocytes with two-thirds being benign nevi. Seventy three lesions were squamous cell carcinomas, and 137 premalignant lesions. Ten percent of the lesions were dermoid nodules.
References
Hampton Roy; Daljit Singh; Richard J. Fugo (2010). Ocular Applications of the Fugo Blade. Lippincott Williams & Wilkins. p. 42. ISBN 978-1-60547-888-3.


