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Lipid-phosphate phosphatase

Lipid-phosphate phosphatase is a engineering topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Lipid-phosphate phosphatase rather than just read about it. In short: The enzyme lipid-phosphate phosphatase (EC 3.1.3.76) catalyzes the reaction (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O ⇌ {\displaystyle \rightleftharpoons } (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase.

Key takeaways

  • Lipid-phosphate phosphatase belongs to engineering; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect Lipid-phosphate phosphatase to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of Lipid-phosphate phosphatase from memory before moving on to harder problems.

Reference excerpt

The enzyme lipid-phosphate phosphatase (EC 3.1.3.76) catalyzes the reaction

(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O ⇌ {\displaystyle \rightleftharpoons } (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase. Other names in common use include hydroxy fatty acid phosphatase, dihydroxy fatty acid phosphatase, hydroxy lipid phosphatase, sEH (ambiguous), and soluble epoxide hydrolase (ambiguous).

See also Epoxide hydrolase 2

References

Morisseau C, Hammock BD (2005). "Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles". Annu. Rev. Pharmacol. Toxicol. 45: 311–33. doi:10.1146/annurev.pharmtox.45.120403.095920. PMID 15822179. Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C (2005). "Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase". Biochemistry. 44 (36): 12179–87. doi:10.1021/bi050842g. PMC 1473036. PMID 16142916. Newman JW, Morisseau C, Hammock BD (2005). "Epoxide hydrolases: their roles and interactions with lipid metabolism". Prog. Lipid Res. 44 (1): 1–51. doi:10.1016/j.plipres.2004.10.001. PMID 15748653. Srivastava PK, Sharma VK, Kalonia DS, Grant DF (2004). "Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure". Arch. Biochem. Biophys. 427 (2): 164–9. doi:10.1016/j.abb.2004.05.003. PMID 15196990. Gomez GA, Morisseau C, Hammock BD, Christianson DW (2004). "Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis". Biochemistry. 43 (16): 4716–23. doi:10.1021/bi036189j. PMID 15096040.

Worked examples

Example 1 — a first encounter with Lipid-phosphate phosphatase

Start with the simplest possible case. Write down what Lipid-phosphate phosphatase claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In engineering, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Lipid-phosphate phosphatase before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Lipid-phosphate phosphatase ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Lipid-phosphate phosphatase

In research
Lipid-phosphate phosphatase appears in engineering research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses Lipid-phosphate phosphatase in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
Lipid-phosphate phosphatase is common in secondary-school and first-year university syllabi. It links to neighbouring topics EC 3.1.3, EC 3.1 stubs, Enzymes of unknown structure, so understanding it makes those chapters shorter.
In everyday life
Look for Lipid-phosphate phosphatase outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.
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How to study Lipid-phosphate phosphatase in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what Lipid-phosphate phosphatase means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain Lipid-phosphate phosphatase out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Lipid-phosphate phosphatase in simple terms?

The enzyme lipid-phosphate phosphatase (EC 3.1.3.76) catalyzes the reaction (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H2O ⇌ {\displaystyle \rightleftharpoons } (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate This enzyme belongs to the family of hydrolases, specifically those acting on ph…

Why does Lipid-phosphate phosphatase matter?

Because it connects several engineering ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Lipid-phosphate phosphatase?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Lipid-phosphate phosphatase.

Tags

  • EC 3.1.3
  • EC 3.1 stubs
  • Enzymes of unknown structure

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