This is a list of hallucinogens, or psychoactive drugs that produce majorly altered states of consciousness.
Psychedelics
Psychedelics, also known as serotonergic psychedelics or classical hallucinogens, are serotonin 5-HT2A receptor agonists and include the following:
Tryptamines such as psilocybin, psilocin, dimethyltryptamine (DMT), 5-MeO-DMT, bufotenin, and α-methyltryptamine (AMT) Phenethylamines such as mescaline, DOM, 2C-B, 25I-NBOMe, and MDA Lysergamides such as LSD, ergine (LSA), ALD-52 (1A-LSD), ETH-LAD, and LSZ Others such as efavirenz, glaucine (possibly), IHCH-7113, mefloquine (possibly), MK-212, quipazine, and RH-34
Dissociatives
Dissociatives, also known as dissociative hallucinogens or dissociative anesthetics, are NMDA receptor antagonists and include the following:
Arylcyclohexylamines such as ketamine (K), phencyclidine (PCP), methoxetamine (MXE), and tiletamine Morphinans such as dextromethorphan (DXM), its active metabolite dextrorphan (DXO), and dextrallorphan (DXA) Adamantanes such as amantadine and memantine Diarylethylamines such as diphenidine, ephenidine, fluorolintane, and methoxphenidine Inhalants such as nitrous oxide (N2O) and xenon Others such as alkyl nitrites (poppers), aptiganel, dexoxadrol, dizocilpine (MK-801 or MK801), etoxadrol, and selfotel
Deliriants
Deliriants are muscarinic acetylcholine receptor antagonists, also known as antimuscarinics or anticholinergics, and include the following:
Tropanes such as atropine, scopolamine (hyoscine), and hyoscyamine Others such as benztropine, biperidin, dimenhydrinate, diphenhydramine, procyclidine, trihexyphenidyl, and tropicamide
κ-Opioid receptor agonists
κ-Opioid receptor agonists with hallucinogenic effects include the following:
Salvinoids like salvinorin A (found in Salvia divinorum), 2-MMSB, 2-EMSB, and RB-64 (22-thiocyanatosalvinorin A) (possibly) Benzomorphans such as pentazocine, phenazocine, and alazocine Morphinans such as levorphanol, levomethorphan, and nalorphine Others such as spiradoline, enadoline, and HZ-2
GABAergics
GABAA receptor agonists
GABAA receptor agonists with hallucinogenic effects include the following:
Muscimol and ibotenic acid, the active constituents of Amanita muscaria mushrooms Gaboxadol (THIP), a synthetic analogue of muscimol
Indirect GABAA receptor agonists
GABAA receptor positive allosteric modulators
Nonbenzodiazepines or Z drugs such as eszopiclone, zaleplon, zolpidem, and zopiclone
GABA reuptake inhibitors
CI-966, a potent GABA transporter 1 (GAT-1) blocker
Oneirogens
Oneirogens, also known as oneirophrenics, have an unknown mechanism of action and include the following:
β-Carbolines and harmala alkaloids such as harmine, harmaline, tetrahydroharmine (THH), 6-methoxyharmalan, and 6-MeO-THH Iboga alkaloids such as ibogaine and noribogaine
Cannabinoids
Cannabinoids with hallucinogenic effects are cannabinoid CB1 receptor agonists and include the following:
Phytocannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC or simply THC) Synthetic cannabinoids such as nabilone, JWH-018, JWH-073, and HU-210 Certain monoacylglycerol lipase (MAGL) inhibitors, which inhibit endocannabinoid metabolism and hence are indirect cannabinoid CB1 receptor agonists, also produce partial or full cannabinoid-like discriminative stimulus effects in animal drug discrimination tests. Conversely, fatty acid amide hydrolase (FAAH) inhibitors, which inhibit endocannabinoid inactivation as well, do not substitute for cannabinoids, at least by themselves.
Other hallucinogens Other hallucinogens that are not known to fall into any of the above groups include the following:
Aminochromes such as adrenochrome and adrenolutin (disputed/controversial) Carbogen, a mixture of carbon dioxide and oxygen gas Glaucine, an aporphine alkaloid known to act on serotonin 5-HT2 receptors among other actions Hallucinogenic bolete mushrooms such as Lanmaoa asiatica (unknown mechanism of action) Hallucinogenic fish, which are reported to cause ichthyoallyeinotoxism Icelandic hallucinogenic lichen ("rock soup") Kambo (sapo), the skin secretions of Phyllomedusa bicolor (giant leaf frog) Kykeon, an ancient drink of the Eleusinian Mysteries of unknown identity with possible hallucinogenic effects (disputed/controversial) Mad honey (Rhododendron; grayanotoxins), a honey with hallucinogenic effects and substantial toxicity Nutmeg, which contains the active constituents myristicin and elemicin (unknown mechanism of action) Sinicuichi (Heimia salicifolia), with possible active constituent of cryogenine (unknown mechanism of action) Soma (haoma), an ancient drink made from a plant of unknown identity with possible hallucinogenic effects Hallucinogen combinations (e.g., ayahuasca, teotlaqualli) Others (e.g., less-well-characterized plant hallucinogens, insect hallucinogens)
See also List of drugs List of designer drugs List of investigational hallucinogens and entactogens List of psychoactive drugs List of substances used in rituals
References
