science

List of investigational PMS/PMDD drugs

List of investigational PMS/PMDD drugs is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand List of investigational PMS/PMDD drugs rather than just read about it. In short: This is a list of investigational PMS/PMDD drugs, or drugs that are currently under development for clinical use for the treatment of premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD) but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Key takeaways

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Reference excerpt

This is a list of investigational PMS/PMDD drugs, or drugs that are currently under development for clinical use for the treatment of premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD) but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action – Indication [Reference]". This list was last comprehensively updated in March 2026. It is likely to become outdated with time.

Under development

Phase 2 Pyridoxamine (RS-8001) – vitamin B6 and antioxidant – PMS [1] Refisolone (ORG-39479; PH-80; PH-80-M; PH80-PMD NS) – vomeropherine / "neurotransmitter receptor modulator" – PMDD [2] Sepranolone (isoallopregnanolone; UC-1010) – GABAA receptor negative allosteric modulator and excitatory neurosteroid – PMDD [3]

Not under development

No development reported Ethinylestradiol/drospirenone (dihydrospirorenone/ethinylestradiol; drospirenone/ethinylestradiol; Petibelle; SH-470; Yasmin; ZK-30595) – combination of ethinylestradiol (estrogen) and drospirenone (progestin) – PMS and PMDD [4] Progesterone intranasal (MetP Progesterone Nasal Gel; MPP 22; ProgestoMat) – progestogen (progesterone receptor agonist) and GABAA receptor positive allosteric modulator (via metabolites) – PMS [5] Progesterone vaginal – progestogen (progesterone receptor agonist) and GABAA receptor positive allosteric modulator (via metabolites) – PMS [6] Research programme: premenstrual syndrome therapeutic - Panacor Bioscience (PB301) – undefined mechanism of action – PMS [7]

Discontinued Ethinylestradiol/levonorgestrel continuous (EE/Levo continuous; EE/LNG continuous; Levo/EE continuous; Levonorgestrel/ethinlyestradiol continuous; Librel; LNG/EE continuous; Lybrel) – combination of ethinylestradiol (estrogen) and levonorgestrel (progestin) – PMS and PMDD [8] Progesterone transdermal (progesterone spray; Progesterone TDS®) – progestogen (progesterone receptor agonist) and GABAA receptor positive allosteric modulator (via metabolites) – PMS [9]

Clinically used drugs

Approved drugs

Hormonal agents Ethinylestradiol/drospirenone low-dose (BAY86-5300; BAY86-5300-YAZ-Flex; Drospirenone/ethinylestradiol; EE20/Drospirenone; EE20/DRSP; Ethinylestradiol-Drospirenone 24+4; Flexyess; SH-T-00186D; Yasmin® 20; Yasminelle; Yaz; Yaz 24+4; Yaz Extended Cycle; YAZ Extended Regimen; Yaz Flex; Yvidually) – combination of ethinylestradiol (estrogen) and drospirenone (progestin) – PMS and PMDD [10] Ethinylestradiol/drospirenone/levomefolic acid (BAY98-7071; Beyaz; EE20/DRSP/L-5MTHF; ethinylestradiol/drospirenone/methyltetrahydrofolate; Safyral; Yasmin Plus; Yaz Flex Plus; Yaz Plus) – combination of ethinylestradiol (estrogen), drospirenone (progestin), and levomefolic acid (vitamin B9) – PMDD [11] Progesterone gel (COL-1620; Crinone; Crinone 4%; Crinone 8%; Crinone8%; OneCrinone; Prochieve; Prochieve4%; Prochieve8%; progesterone vaginal gel 4%; progesterone vaginal gel 8%) – progestogen (progesterone receptor agonist) and GABAA receptor positive allosteric modulator (via metabolites) – PMS [12] Progesterone vaginal (Utrogestan) – progestogen (progesterone receptor agonist) and GABAA receptor positive allosteric modulator (via metabolites) – PMS [13]

Antidepressants Fluoxetine (LY-110140; Prozac; Prozac Weekly; Reneuron; Sarafem) – selective serotonin reuptake inhibitor (SSRI) – PMDD [14] Paroxetine (Aropax; BRL 29060; BRL 29060A; Deroxat; Divarius; FG 7051; Frosinor; Motivan; NNC 207051; Paxil; Paxil CR; Seroxat; SI 211103; Tagonis) – selective serotonin reuptake inhibitor (SSRI) – PMDD [15] Sertraline (Aremis; Besitran; CP 51974; CP 51974 01; Gladem; J Zoloft; Lustral; Serad; Serlain; Tatig; Zoloft) – selective serotonin reuptake inhibitor (SSRI) – PMDD [16]

Off-label drugs

Hormonal agents 5α-Reductase inhibitors (e.g., dutasteride) (via neurosteroid synthesis inhibition) Androgens (androgen receptor agonists) (e.g., danazol) GnRH agonists (e.g., leuprorelin) and GnRH antagonists (e.g., elagolix, relugolix) (with or without add-back estrogen–progestogen therapy) Neurosteroids acting as GABAA receptor positive allosteric modulators (e.g., brexanolone (allopregnanolone), zuranolone, ganaxolone) Other contraceptive and non-contraceptive estrogen–progestogen therapies Other progesterone formulations and progestogens Selective progesterone receptor modulators (SPRMs) (e.g., ulipristal acetate) Spironolactone (Aldactone) – antimineralocorticoid (mineralocorticoid receptor antagonist), other actions

Psychiatric medications Anxiolytics (e.g., benzodiazepines (e.g., alprazolam), buspirone) Other selective serotonin reuptake inhibitors (SSRIs) (e.g., citalopram, escitalopram) Other serotonergic antidepressants (e.g., venlafaxine, duloxetine, clomipramine)

See also List of investigational drugs List of investigational sex-hormonal agents List of investigational antidepressants

References

External links AdisInsight - Springer

Worked examples

Example 1 — a first encounter with List of investigational PMS/PMDD drugs

Start with the simplest possible case. Write down what List of investigational PMS/PMDD drugs claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to List of investigational PMS/PMDD drugs before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about List of investigational PMS/PMDD drugs ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of List of investigational PMS/PMDD drugs

In research: List of investigational PMS/PMDD drugs appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses List of investigational PMS/PMDD drugs in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: List of investigational PMS/PMDD drugs is common in secondary-school and first-year university syllabi. It links to neighbouring topics Experimental psychiatric drugs, Lists of investigational drugs, so understanding it makes those chapters shorter.
In everyday life: Look for List of investigational PMS/PMDD drugs outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

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