science

List of investigational aggression drugs

List of investigational aggression drugs is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand List of investigational aggression drugs rather than just read about it. In short: This is a list of investigational aggression drugs, or drugs that are currently under development for clinical use in the treatment of aggression but are not yet approved. Drugs used to treat aggression may also be known as "serenics".

Key takeaways

List of investigational aggression drugs belongs to science; place it in that map before memorising details.
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Connect List of investigational aggression drugs to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of List of investigational aggression drugs from memory before moving on to harder problems.

Reference excerpt

This is a list of investigational aggression drugs, or drugs that are currently under development for clinical use in the treatment of aggression but are not yet approved. Drugs used to treat aggression may also be known as "serenics". Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. This list was last comprehensively updated in February 2025. It is likely to become outdated with time.

Under development

Phase 3 Molindone (AFX 2201; EN-1733A; -810; SPN-810M; Zalvari) – antipsychotic (dopamine D2 receptor antagonist, serotonin 5-HT2B receptor antagonist, and other actions) – specifically for aggression in children and adolescents with attention-deficit hyperactivity disorder (ADHD)

Phase 2 KNX-100 (SOC-1) – 15-lipoxygenase (15-LOX; ALOX15) inhibitor and oxytocin-like drug or indirect oxytocin receptor modulator [1] [2] Vafidemstat (ORY-2001) – lysine-specific demethylase 1 (LSD1; KDM1A) and monoamine oxidase B (MAO-B) inhibitor

Preclinical KNX-101 – 15-lipoxygenase (15-LOX; ALOX15) inhibitor SRX251 – vasopressin V1A receptor antagonist – no recent development since 2007

Not under development

No development reported Eltoprazine (DU-28853) – serotonin 5-HT1A and 5-HT1B receptor agonist and serotonin 5-HT2C receptor antagonist Zolmitriptan (ML-004) – serotonin 5-HT1B and 5-HT1D receptor agonist

Development discontinued Batoprazine – serotonin 5-HT1A and 5-HT1B receptor agonist Mibampator (LY-451395) – ionotropic glutamate AMPA receptor positive allosteric modulator Olanzapine intranasal (INP-105; POD olanzapine) – atypical antipsychotic (non-selective monoamine receptor modulator) Risperidone extended-release (Risperisphere) – atypical antipsychotic (non-selective monoamine receptor modulator)

Formal development never or not yet started Antiandrogens (e.g., cyproterone acetate, medroxyprogesterone acetate, GnRH modulators) Other serotonin 5-HT1A and 5-HT1B receptor agonists (e.g., fluprazine) Selective 5-HT1B receptor agonists (e.g., anpirtoline, CP-94253) Serotonin 5-HT1B and 5-HT1D receptor agonists (e.g., PGI-7043) Serotonin 5-HT2B receptor antagonists (e.g., MW073) Serotonin 5-HT2C receptor agonists (e.g., lorcaserin) Serotonin releasing agents (e.g., fenfluramine) Trace amine-associated receptor 1 (TAAR1) agonists (e.g., RO5263397)

Clinically used drugs

Approved drugs Olanzapine (Zyprexa) – atypical antipsychotic (non-selective monoamine receptor modulator) Paliperidone (Invega) – atypical antipsychotic (non-selective monoamine receptor modulator) Risperidone (Risperdal) – atypical antipsychotic (non-selective monoamine receptor modulator)

Off-label drugs α2-Adrenergic receptor agonists (e.g., clonidine, dexmedetomidine, guanfacine) Anticonvulsants (e.g., valproic acid, divalproex, carbamazepine, oxcarbazepine, phenytoin, lamotrigine, topiramate, gabapentin, tiagabine) Antidepressants (e.g., selective serotonin reuptake inhibitors (SSRIs) like sertraline) (but may exacerbate aggression) Benzodiazepines (e.g., diazepam, lorazepam, midazolam) (but may exacerbate aggression) Beta blockers (β-adrenergic receptor antagonists) (e.g., propranolol, pindolol, nadolol) Cannabinoids (e.g., cannabis, dronabinol, nabilone) Lithium – mood stabilizer with unknown mechanism of action Norepinephrine reuptake inhibitors (NRIs) (e.g., atomoxetine) Other antipsychotics (e.g., aripiprazole, chlorpromazine, droperidol, haloperidol, quetiapine, thioridazine) Psychostimulants (e.g., amphetamine, methylphenidate) (but may exacerbate aggression)

See also List of investigational drugs List of investigational agitation drugs List of investigational antipsychotics List of investigational borderline personality disorder drugs List of investigational autism and pervasive developmental disorder drugs Serenic (antiaggressive drug) Anger § Medication therapy Entactogen

References

External links AdisInsight - Springer

Worked examples

Example 1 — a first encounter with List of investigational aggression drugs

Start with the simplest possible case. Write down what List of investigational aggression drugs claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to List of investigational aggression drugs before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about List of investigational aggression drugs ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of List of investigational aggression drugs

In research: List of investigational aggression drugs appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses List of investigational aggression drugs in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: List of investigational aggression drugs is common in secondary-school and first-year university syllabi. It links to neighbouring topics Experimental psychiatric drugs, Lists of investigational drugs, so understanding it makes those chapters shorter.
In everyday life: Look for List of investigational aggression drugs outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

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Why does List of investigational aggression drugs matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

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Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

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