science

List of investigational antipsychotics

List of investigational antipsychotics is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand List of investigational antipsychotics rather than just read about it. In short: This is a list of investigational antipsychotics, or drugs that are currently under development for clinical use as antipsychotics for the treatment of schizophrenia and other psychotic disorders but are not yet approved. Psychotic disorders include schizophrenia, schizoaffective disorder, and others such as psychotic depression, Parkinson's disease psychosis, and Alzheimer's disease psychosis.

Key takeaways

List of investigational antipsychotics belongs to science; place it in that map before memorising details.
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Reference excerpt

This is a list of investigational antipsychotics, or drugs that are currently under development for clinical use as antipsychotics for the treatment of schizophrenia and other psychotic disorders but are not yet approved. Psychotic disorders include schizophrenia, schizoaffective disorder, and others such as psychotic depression, Parkinson's disease psychosis, and Alzheimer's disease psychosis. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action – Indication [Reference]". This list was last comprehensively updated in June 2026. It is likely to become outdated with time.

Under development

Preregistration Olanzapine long acting injectable (mdc-TJK; TEV-749; TV-44749) – dopamine D1 receptor antagonist, dopamine D2 receptor antagonist, serotonin 5-HT2A receptor antagonist, and other actions – schizophrenia [1] Roluperidone (CYR-101; MIN-101; MT-210) – serotonin 5-HT2A receptor antagonist, sigma σ2 receptor antagonist, and other actions – schizophrenia [2]

Phase 3 Brilaroxazine (RP-5000; RP-5063; oxaripiprazole) – dopamine D2 receptor partial agonist, serotonin 5-HT2A receptor antagonist, and other actions – schizophrenia [3] Direclidine (HTL-0016878; NBI-1117568; NBI-568) – muscarinic acetylcholine M4 receptor agonist – schizophrenia [4] Evenamide (EA-8001; NW-3509; NW-3509A) – voltage-gated sodium channel (VGSC) blocker – schizophrenia [5] Iclepertin (BI-425809) – glycine transporter 1 (GlyT1) inhibitor – schizophrenia [6] N-Methylamisulpride (LB-102) – dopamine D2 and D3 receptor antagonist, serotonin 5-HT2B receptor antagonist, and serotonin 5-HT7 receptor antagonist – schizophrenia [7] Remlifanserin (ACP-204) – serotonin 5-HT2A receptor inverse agonist – psychotic disorders [8] Risperidone extended release (LYN-005) – dopamine D2 receptor antagonist and serotonin 5-HT2A receptor antagonist – schizophrenia, schizoaffective disorder [9] Ulotaront (SEP-363856; SEP-856) – trace amine-associated receptor 1 (TAAR1) agonist and serotonin 5-HT1A receptor agonist – schizophrenia [10] Valbenazine (Dysval; Ingrezza; MT-5199; NBI-98854; Remleas) – vesicular monoamine transporter 2 (VMAT2) blocker and monoamine depleting agent – schizophrenia [11] Xanomeline enteric coated (BMS-986519; KarX-EC; LY-246708; Memcor; NNC-110232) – muscarinic acetylcholine M1 and M4 receptor agonist – psychotic disorders [12] Xanomeline/trospium chloride (BMS-986510; Cobenfy; KarXT; trospium/LY-246708; trospium/xanomeline) – combination of xanomeline (muscarinic acetylcholine M1 and M4 receptor agonist) and trospium chloride (peripherally selective non-selective muscarinic acetylcholine receptor antagonist) – psychotic disorders [13]

Phase 2/3 AVN-211 (CD-008-0173) – serotonin 5-HT6 receptor antagonist – schizophrenia [14] Deudextromethorphan (AVP-786; CTP-786; d-DM; d6-DM; deudextromethorphan/quinidine; deuterated dextromethorphan; deuterated-DM) – combination of deudextromethorphan (sigma receptor agonist, ionotropic glutamate NMDA receptor antagonist, serotonin reuptake inhibitor, other actions) and quinidine (CYP2D6 inhibitor) – schizophrenia [15] Sodium benzoate (benzoate; Clozaben; NaBen; SND-51; SND-11; SND-12; SND-13; SND-14; Tannquilynne; Ω-NaBen) – D-amino acid oxidase inhibitor – schizophrenia [16]

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Worked examples

Example 1 — a first encounter with List of investigational antipsychotics

Start with the simplest possible case. Write down what List of investigational antipsychotics claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to List of investigational antipsychotics before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about List of investigational antipsychotics ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of List of investigational antipsychotics

In research: List of investigational antipsychotics appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses List of investigational antipsychotics in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: List of investigational antipsychotics is common in secondary-school and first-year university syllabi. It links to neighbouring topics Antipsychotics, Experimental psychiatric drugs, Lists of investigational drugs, so understanding it makes those chapters shorter.
In everyday life: Look for List of investigational antipsychotics outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study List of investigational antipsychotics in 20 minutes

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Frequently asked questions

What is List of investigational antipsychotics in simple terms?

Why does List of investigational antipsychotics matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study List of investigational antipsychotics?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on List of investigational antipsychotics.