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List of investigational bipolar disorder drugs

List of investigational bipolar disorder drugs is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand List of investigational bipolar disorder drugs rather than just read about it. In short: This is a list of investigational bipolar disorder drugs, or drugs that are currently under development for clinical use for the treatment of bipolar disorder (manic depression) and related conditions but are not yet approved. Bipolar disorder and related conditions include bipolar I disorder, bipolar II disorder, cyclothymia, manic episodes, bipolar depression, and schizoaffective disorder (bipolar/manic and mixed…

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Reference excerpt

This is a list of investigational bipolar disorder drugs, or drugs that are currently under development for clinical use for the treatment of bipolar disorder (manic depression) and related conditions but are not yet approved. Bipolar disorder and related conditions include bipolar I disorder, bipolar II disorder, cyclothymia, manic episodes, bipolar depression, and schizoaffective disorder (bipolar/manic and mixed types). Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action – Indication [Reference]". This list was last comprehensively updated in May 2026. It is likely to become outdated with time.

Under development

Preregistration Lurasidone (DSP-1349M; Latuda; SM-13496; SMP-13496) – atypical antipsychotic (non-selective monoamine receptor modulator) – bipolar disorders [1]

Phase 3 ALM-008 – undefined mechanism of action (mood stabilizer) – bipolar disorders [2] Azetukalner (1OP-2198; encukalner; VRX-621698; XEN-1101; XPF-008) – Kv7.2 and Kv7.3 potassium channel opener – bipolar depression [3] Brenipatide (LY-3537031) – glucagon-like peptide-1 (GLP-1) receptor agonist and gastric inhibitory polypeptide (GIP) receptor agonist – bipolar disorders [4] Brexpiprazole (Lu-AF41156; OPC-34712; OPDC-34712; Rexulti; Rxulti) – atypical antipsychotic (non-selective monoamine receptor modulator) – bipolar disorders [5] Cycloserine/lurasidone (Cyclurad; D-cycloserine/lurasidone; lurasidone/cycloserine; NRX-101) – combination of cycloserine (ionotropic glutamate NMDA receptor glycine site partial agonist) and lurasidone (atypical antipsychotic/non-selective monoamine receptor modulator) – bipolar depression [6] Endoxifen (4-hydroxy-N-desmethyltamoxifen; Z-endoxifen) – selective estrogen receptor modulator (SERM) and protein kinase C (PKC) inhibitor – bipolar disorders [7] Lumateperone (Caplyta; ITI-007; ITI-722) – atypical antipsychotic (non-selective monoamine receptor modulator) – bipolar disorders [8] Risperidone extended release (LYN-005) – atypical antipsychotic (non-selective monoamine receptor modulator) – schizoaffective disorder [9] SEP-4199 (non-racemic amisulpride; aramisulpride/esamisulpride [85:15 ratio]) – dopamine D2 and D3 receptor antagonist and serotonin 5-HT2B and 5-HT7 receptor antagonist – bipolar depression [10] Xanomeline/trospium chloride (BMS-986510; Cobenfy; KarXT; LY-246708/trospium chloride) – combination of xanomeline (non-selective muscarinic acetylcholine receptor agonist) and trospium chloride (peripherally selective non-selective muscarinic acetylcholine receptor antagonist) – bipolar disorders [11]

Phase 2/3 Opakalim (BHV-7000; BPN-25203; KB-3061) – Kv7.2 and Kv7.3 potassium channel opener – bipolar disorders [12]

Phase 2 Aldesleukin (ILT-101; interleukin-2; IL2; IL-2) – recombinant interleukin-2 (IL-2) replacement (interleukin-2 receptor agonist) – bipolar disorders [13] Amdiglurax (ALTO-100; NSI-189) – unknown mechanism of action (hippocampal neurogenesis stimulant and indirect brain-derived neurotrophic factor (BDNF) modulator) – bipolar depression [14] Brilaroxazine (RP-5000; RP-5063) – atypical antipsychotic (non-selective monoamine receptor modulator) – schizoaffective disorder [15] Cenobamate (ONO-2017; Ontozry; senovamate; X-Copri; XCopri; YKP-3089) – voltage-gated sodium channel (VGSC) blocker and GABA release enhancer – bipolar disorders [16] Desmethyl cariprazine prodrug (ABBV-932; RGH-932) – atypical antipsychotic (non-selective monoamine receptor modulator) – bipolar depression, bipolar disorders [17] Direclidine (HTL-0016878; NBI-1117568; NBI-568) – muscarinic acetylcholine M4 receptor agonist – bipolar I disorders [18] Ebselen (DR-3305; ebselene; ebseleno; ebselenum; harmokisane; PZ-51; SPI-1005; SPI-3005) – various actions – bipolar disorders [19] Elunetirom (ABX-002) – thyroid hormone receptor beta (TRβ) agonist – bipolar depression [20] Icalcaprant (ABBV-1354; CVL-354) – κ-opioid receptor antagonist – bipolar depression [21] JNJ-8942 – undefined mechanism of action – bipolar disorders [22] JNJ-18038683 – serotonin 5-HT7 receptor antagonist – bipolar disorders [23] JNJ-55308942 – purine P2X7 receptor antagonist – bipolar depression [24] Lithium cocrystal (AL-001-Alzamend Neuro; lithium salicylate/L-proline cocrystal) – undefined mechanism of action (mood stabilizer) – bipolar disorders, bipolar I disorders [25] N-Methylamisulpride (LB-102) – dopamine D2 and D3 receptor antagonist and serotonin 5-HT2B and 5-HT7 receptor antagonist – bipolar depression [26] Navacaprant (BTRX-140; BTRX-335140; CYM-53093; NMRA-140; NMRA-335140) – κ-opioid receptor antagonist – bipolar depression [27] OSU-6162 (PNU-9639; PNU-96391; PNU-96391A) – dopamine D2 receptor agonist, serotonin 5-HT2A receptor agonist, and so-called "dopamine stabilizer" – bipolar depression [28] Psilocybin (COMP360; COMP-360) – non-selective serotonin receptor agonist, serotonin 5-HT2A receptor agonist, and psychedelic hallucinogen – bipolar depression [29] RAP-219 – AMPA receptor negative allosteric modulator – bipolar disorders [30] Vortioxetine (Brintellix; LU-AA21004; LuAA 21004; Trintellix; Vortidif) – serotonin reuptake inhibitor, serotonin 5-HT1A and 5-HT1B receptor agonist, and serotonin 5-HT1D, 5-HT3, and 5-HT7 receptor antagonist – bipolar depression [31] Zuranolone (BIIB-125; S-812217; SAGE-217; SGE-797; Zurzuvae) – GABAA receptor positive allosteric modulator and neurosteroid – bipolar depression [32]

Phase 1/2 Cariprazine (cariprazine depot) – atypical antipsychotic (non-selective monoamine receptor modulator) – bipolar disorders [33]

Phase 1 Brilaroxazine (RP-5000; RP-5063) – atypical antipsychotic (non-selective monoamine receptor modulator) – bipolar disorders [34] CB03-154 (CB-03; CB-003) – Kv7.2 and Kv7.3 potassium channel opener – bipolar disorders [35] Scopolamine (DPI-385-CVS; DPI-386; DPI-386 Nasal Gel; DPI-386-SG; DPI-386-SS; DPI-387; DPI-521-CG; DPI-550-TBI; Inscop spray) – non-selective muscarinic acetylcholine receptor antagonist – bipolar depression [36]

Clinical phase unknown LTX-001 – glutaminase inhibitor – bipolar disorders [37] Quetiapine oral suspension – non-selective monoaminer eceptor modulator – bipolar disorders [38]

Preclinical Estianeptine ((S)-tianeptine; TNX-4300) – peroxisome proliferator-activated receptor PPARβ/δ and PPARγ agonist [39]

… excerpt ends here. Continue reading the full article.

Worked examples

Example 1 — a first encounter with List of investigational bipolar disorder drugs

Start with the simplest possible case. Write down what List of investigational bipolar disorder drugs claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to List of investigational bipolar disorder drugs before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about List of investigational bipolar disorder drugs ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of List of investigational bipolar disorder drugs

In research: List of investigational bipolar disorder drugs appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses List of investigational bipolar disorder drugs in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: List of investigational bipolar disorder drugs is common in secondary-school and first-year university syllabi. It links to neighbouring topics Experimental psychiatric drugs, Lists of investigational drugs, Treatment of bipolar disorder, so understanding it makes those chapters shorter.
In everyday life: Look for List of investigational bipolar disorder drugs outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

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