science

List of investigational fibromyalgia drugs

List of investigational fibromyalgia drugs is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand List of investigational fibromyalgia drugs rather than just read about it. In short: This is a list of investigational fibromyalgia drugs, or drugs that are currently under development for clinical use in the treatment of fibromyalgia but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Key takeaways

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Reference excerpt

This is a list of investigational fibromyalgia drugs, or drugs that are currently under development for clinical use in the treatment of fibromyalgia but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action [Reference]". This list was last comprehensively updated in September 2025. It is likely to become outdated with time.

Under development

Preregistration Esreboxetine ((S,S)-Reboxetine; AXS-14; PNU-165442G) – norepinephrine reuptake inhibitor (NRI) [1]

Phase 3 Pregabalin controlled release (GRO-12; Lyrica CR; Pregabalin CR; Pregabalin ER) – gabapentinoid (α2δ subunit-containing voltage-gated calcium channel ligand) [2]

Phase 2 Celecoxib/famciclovir (famciclovir/celecoxib; IMC-1) – combination of celecoxib (COX inhibitor/NSAID) and famciclovir (antiviral) [3] Mirtazapine (Avanza; Azamianserin; ME-2040; Mepirzapin; Norset; ORG-3770; Promyrtil; Reflex; Remergil; Remergon; Remeron; Rexer; Zispin) – tetracyclic antidepressant (TeCA) (non-selective monoamine receptor modulator and other actions) [4] ONO-1110 – endocannabinoid synthesis regulator and indirect cannabinoid receptor modulator [5] [6] [7] Opiranserin (Unafra; VVZ-000149; VVZ-149) – glycine transporter 2 (GlyT2) blocker, purine P2X3 receptor antagonist, and serotonin 5-HT2A receptor antagonist [8] Psilocybin (PFN™; TRP-8802; TRP-8803; TRP-8804; TRYP-0082) – non-selective serotonin receptor agonist and psychedelic hallucinogen [9] Rozanolixizumab (Rystiggo; UCB-7665) – monoclonal antibody against neonatal Fc receptor (FcRn) [10]

Research Celecoxib/valacyclovir (IMC-2; valacyclovir/celecoxib) – combination of celecoxib (COX inhibitor/NSAID) and valacyclovir (antiviral) [11]

Not under development

Suspended ETX-155 – GABAA receptor positive allosteric modulator and neurosteroid [12]

No development reported ASP-0819 (ASP0819) – calcium-activated potassium channel opener [13] CT-38 – corticotropin-releasing factor CRF2 receptor agonist [14] Elcubragistat (ABX-1431; Lu-AG06466) – monoacylglycerol lipase (MAGL) inhibitor [15] Galcanezumab (Emgality; LY-2951742) – monoclonal antibody against calcitonin gene-related peptide (CGRP) [16] Lacosamide (ADD-234037; Erlosamide; Harkoseride; SPM-927; SPM-929; Vimpat; Vimpato) – various actions [17] Pregabalin controlled release (Pregabalin XR; Regabatin XR) – gabapentinoid (α2δ subunit-containing voltage-gated calcium channel ligand) [18] Research programme: cannabis extract therapeutics - Cannabis Science – cannabinoid receptor modulators [19] Research programme: pregabalin gastric-retentive - ProTect (NPRx-1000; PRTT-200) – gabapentinoid (α2δ subunit-containing voltage-gated calcium channel ligand) [20] Ropinirole (Adartrel; Repreve; Requip) – dopamine D2, D3, and D4 receptor agonist [21] SER-282 – undefined mechanism of action [22] Somatropin (Nutrophin; Nutropin; SMP-140) – growth hormone (GH) replacement [23] Sunobinop (IMB-115; IT-1315; RSC-117957; S-117957; V-117957) – nociceptin receptor agonist [24]

Discontinued AD-337 – serotonin–norepinephrine reuptake inhibitor (SNRI) [25] Ampreloxetine (TD-9855) – serotonin–norepinephrine reuptake inhibitor (SNRI) [26] ASP-8062 – GABAB receptor positive allosteric modulator [27] Desvenlafaxine (DVS-233; MD-120; O-desmethylvenlafaxine; Pristiq; WY-45233) – serotonin–norepinephrine reuptake inhibitor (SNRI) [28] Droxidopa (3,4-dihydroxyphenylserine; 3,4-threo-DOPS; DOPS; Northera; threo-DOPS) – norepinephrine precursor and indirect non-selective adrenergic receptor agonist [29] Eslicarbazepine acetate (Aptiom; BIA 2-093; ESL; Exalief; SEP-0002093; SEP-2093; Stedesa; Zebinix) – sodium channel blocker [30] Faxeladol (GRT-9906; GRT9906) – μ-opioid receptor (MOR) agonist and serotonin–norepinephrine reuptake inhibitor (SNRI) (tramadol analogue) [31] Fremanezumab (Ajovy; LBR-101; PF-04427429; PF-4427429; RN-307; TEV-48125) – monoclonal antibody against calcitonin gene-related peptide (CGRP) [32] Galantamine (galanthamine; GP-37267; Nivalin; R-113675; Razadyne; Reminyl) – acetylcholinesterase inhibitor [33] Ibutamoren (L-163191; LUM-201; MK-0677; MK-677; Oratrope) – ghrelin receptor agonist and growth hormone secretagogue [34] Interferon α2a (IFN-α lozenges; MOR-22; Veldona) – interferon α stimulant and immunomodulator [35] Nabilone (Cesamet) – cannabinoid CB1 and CB2 receptor agonist [36] PF-738502 – undefined mechanism of action [37] Pramipexole (BI-Sifrol; Daquiran; Mirapex; Mirapexin; Pexola; Sifrol; SND-919; SND-919Y) – dopamine D2, D3, and D4 receptor agonist [38] Pregabalin sustained release (EASOPSRTFP) – gabapentinoid (α2δ subunit-containing voltage-gated calcium channel ligand) [39] Radafaxine (GW-353162; (2S,3S)-hydroxybupropion) – norepinephrine–dopamine reuptake inhibitor (NDRI) [40] Research programme: fibromyalgia therapies - Cypress Bioscience/Georgetown University – undefined mechanism of action [41] Rotigotine transdermal (Leganto; N-0437; N-0923; Neupro; Nubrenza; SPM-962) – non-selective dopamine receptor agonist and other actions [42] Sodium oxybate (γ-hydroxybutyrate; GHB; JZP-6; KEY-10; Xyrem) – GABAB receptor agonist and GHB receptor agonist [43] Terguride (Dironyl; Mysalfon; SH-406; Teluron; Transdihydrolisuride; VUFB-6638; ZK-31224) – non-selective dopamine receptor agonist, non-selective serotonin receptor modulator, and other actions [44] Tizanidine (AN-021A; AN-021; DS-103282-CH; DS-103282; Sirdalud; Ternelin; Zanaflex) – α2-adrenergic receptor agonist [45] Ubidecarenone (Bio-Quinone Q10; Coenzyme Q10; CoQ10; Neuquinon; Q-Gel; UbiQGel; Ubiquinone; Vitaline) – antioxidant and immunomodulator [46] ZYN-001 (δ9-THC D-glyceric acid ester; THC prodrug transdermal patch) – cannabinoid CB1 and CB2 receptor agonist [47]

Clinically used drugs

Approved Cyclobenzaprine sublingual (KRL-102; TNX-102; Tonmya) – tricyclic antidepressant (TCA) (non-selective monoamine reuptake inhibitor and monoamine receptor modulator) [48] Duloxetine (Ariclaim; Cymbalta; LY-227942; LY-248686; Xeristar; Yentreve) – serotonin–norepinephrine reuptake inhibitor (SNRI) [49] Milnacipran (Dalcipran; F-2207; Impulsor; Ixel; Joncia; Midacipran; Midalcipran; Savella; TN-912; Toledomin) – serotonin–norepinephrine reuptake inhibitor (SNRI) [50] Pregabalin (CI-1008; isobutylgaba; Lyrica; PD-144723) – gabapentinoid (α2δ subunit-containing voltage-gated calcium channel ligand) [51]

… excerpt ends here. Continue reading the full article.

Worked examples

Example 1 — a first encounter with List of investigational fibromyalgia drugs

Start with the simplest possible case. Write down what List of investigational fibromyalgia drugs claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to List of investigational fibromyalgia drugs before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about List of investigational fibromyalgia drugs ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of List of investigational fibromyalgia drugs

In research: List of investigational fibromyalgia drugs appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses List of investigational fibromyalgia drugs in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: List of investigational fibromyalgia drugs is common in secondary-school and first-year university syllabi. It links to neighbouring topics Lists of investigational drugs, so understanding it makes those chapters shorter.
In everyday life: Look for List of investigational fibromyalgia drugs outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

What is List of investigational fibromyalgia drugs in simple terms?

Why does List of investigational fibromyalgia drugs matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

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