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List of investigational obsessive–compulsive disorder drugs

List of investigational obsessive–compulsive disorder drugs is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand List of investigational obsessive–compulsive disorder drugs rather than just read about it. In short: This is a list of investigational obsessive–compulsive disorder drugs, or drugs that are currently under development for clinical use in the treatment of obsessive–compulsive disorder (OCD) but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Key takeaways

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Reference excerpt

This is a list of investigational obsessive–compulsive disorder drugs, or drugs that are currently under development for clinical use in the treatment of obsessive–compulsive disorder (OCD) but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action [Reference]". This list was last comprehensively updated in September 2025. It is likely to become outdated with time.

Under development

Phase 2 BP-1.4979 (BP-1.4979; BP-14979; BP14979) – dopamine D3 receptor partial agonist Psilocybin (SYNP-101; synthetic psilocybin) – non-selective serotonin receptor agonist and psychedelic hallucinogen [1]

Phase 1 Carbidopa/oxytriptan (EVX-101; carbidopa/oxitriptan; carbidopa/5-HTP) – combination of carbidopa (aromatic L-amino-acid decarboxylase (AAAD) inhibitor) and oxytriptan (5-HTP; serotonin precursor) [2] Psilocybin (MLS-101) – non-selective serotonin receptor agonist and psychedelic hallucinogen [3]

Preclinical HBL20017 – non-hallucinogenic non-selective serotonin receptor agonist

Research Research programme: obsessive-compulsive disorder therapeutics - Serenatis Bio – dopamine modulators and glutamate modulators [4]

Not under development

No development reported Agomelatine (AGO-178; AGO178C; Alodil; Melitor; S-20098; S-20098-F55; Thymanax; Valdoxan; Vestin) – melatonin MT1 and MT2 receptor agonist and weak serotonin 5-HT2C receptor antagonist [5] Ketamine (AWKN-001; AWKN-P-001) – ionotropic glutamate NMDA receptor antagonist [6] Research programme: Cannabidiol therapeutics - Phytecs (4'-F-CBD; fluorinated cannabidiol; HUF-102; HUF-103) – cannabinoid receptor modulators [7] Research programme: cannabis extract therapeutics - Cannabis Science (CBIS compounds) – cannabinoid receptor modulators [8] Research programme: central nervous system therapeutics - AbbVie/Rugen – undefined mechanism of action [9] Research programme: GPCR modulators - Nxera Pharma – various actions [10] Research programme: orexin receptor antagonists - Rottapharm (CR-5542) – orexin receptor antagonists [11] Research programme: serotonin reuptake inhibitors/serotonin 1A receptor antagonists - Pfizer (SSA-426; SSRI/5HT1A receptor antagonist; WAY-163426; WAY-211612; WAY-253752; WAY-426) – serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists [12] Risperidone (JNJ-410397-AAA; R-64766; R064766; Risperdal; Risperdal Consta; Risperdal Depot) – atypical antipsychotic (non-selective monoamine receptor modulator [13]

Discontinued Bitopertin (DISC-1459; R-1678; RG-6178; RG1678; RO-4917838) – glycine transporter 1 (GlyT1) inhibitor and glycine reuptake inhibitor [14] Cycloserine (D-cycloserine; TIK-101) – ionotropic glutamate NMDA receptor partial agonist and other actions [15] DSP-1181 – serotonin 5-HT1A receptor agonist [16] [17] F-14258 – serotonin 5-HT1B and 5-HT1D receptor antagonist [18] Mavoglurant (AFQ-056; STP-7) – metabotropic glutamate mGlu5 receptor antagonist [19] Minocycline (NPL-2003) – various actions and "glutamate modulator" [20] Naltrexone/fluoxetine (fluoxetine/naltrexone; OREX-004) – combination of naltrexone (opioid receptor antagonist) and fluoxetine (selective serotonin reuptake inhibitor (SSRI)) [21] Ondansetron (Setrodon; TO-2061) – serotonin 5-HT3 receptor antagonist [22] Ro-600175 (Ro600175) – serotonin 5-HT2C receptor agonist [23] Roxindole (EMD-49980) – non-selective monoamine receptor modulator [24] SB-200646 (SB-200646A) – serotonin 5-HT2B and 5-HT2C receptor antagonist [25] Secretin (INN-329; RG-1068; SecreFlo; synthetic human secretin) – secretin receptor agonist and medical imaging enhancer [26] [27] Troriluzole (BHV-4157; Dazluma; FC-4157; trigriluzole) – various actions (riluzole prodrug) [28]

Formal development never or not yet started Antiandrogens (e.g., flutamide, cyproterone acetate, triptorelin) Cannabinoids (e.g., nabilone, tetrahydrocannabinol (THC), cannabis) Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., celecoxib, naproxen) Rituximab (Rituxan) – monoclonal antibody against CD20 Serotonin 5-HT6 receptor agonists (e.g., WAY-181187, WAY-208466) Tolcapone (Tasmar) – catechol-O-methyltransferase (COMT) inhibitor

Clinically used drugs

Approved drugs

Selective serotonin reuptake inhibitors (SSRIs) Escitalopram (Cipralex; Entact; Lexapro; LU-26054; MLD-55; (S)-citalopram; Seroplex; Sipralex; Sipralexa) – selective serotonin reuptake inhibitor (SSRI) [29] Fluoxetine (LY-110140; Prozac; Prozac Weekly; Reneuron; Sarafem) – selective serotonin reuptake inhibitor (SSRI) [30] Fluoxetine – selective serotonin reuptake inhibitor (SSRI) [31] Fluvoxamine (Depromel; Luvox; Luvox CR; SME-3110) – selective serotonin reuptake inhibitor (SSRI) and sigma σ1 receptor agonist [32] Paroxetine (Aropax; BRL-29060; Deroxat; Divarius; FG-7051; Frosinor; Motivan; NNC-207051; Paxil; Paxil CR; Seroxat; SI-211103; Tagonis) – selective serotonin reuptake inhibitor (SSRI) [33] Paroxetine (Dropax; Dropaxin; Serestill) – selective serotonin reuptake inhibitor (SSRI) [34] Sertraline (Aremis; Besitran; CP-51974; CP-51974-01; Gladem; J Zoloft; Lustral; Serad; Serlain; Tatig; Zoloft) – selective serotonin reuptake inhibitor (SSRI) [35]

Tricyclic antidepressants (TCAs) Clomipramine (Anafranil) – tricyclic antidepressant (TCA) (non-selective monoamine reuptake inhibitor and receptor modulator) [36]

Off-label drugs Anticonvulsants (e.g., lamotrigine, topiramate) Antipsychotics (non-selective monoamine receptor modulators) (e.g., aripiprazole, haloperidol, olanzapine, quetiapine, risperidone) Anxiolytics (e.g., benzodiazepines, buspirone) Entactogens (e.g., midomafetamine/MDMA) Monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine, tranylcypromine, moclobemide) NMDA receptor antagonists (e.g., memantine, ketamine) Serotonergic psychedelics (e.g., psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine (DMT)) Serotonin 5-HT3 receptor antagonist (e.g., ondansetron, granisetron, tropisetron) Serotonin–norepinephrine reuptake inhibitors (SNRIs) (e.g., desvenlafaxine, duloxetine, venlafaxine) Stimulants (e.g., dextroamphetamine)

Worked examples

Example 1 — a first encounter with List of investigational obsessive–compulsive disorder drugs

Start with the simplest possible case. Write down what List of investigational obsessive–compulsive disorder drugs claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to List of investigational obsessive–compulsive disorder drugs before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about List of investigational obsessive–compulsive disorder drugs ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of List of investigational obsessive–compulsive disorder drugs

In research: List of investigational obsessive–compulsive disorder drugs appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses List of investigational obsessive–compulsive disorder drugs in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: List of investigational obsessive–compulsive disorder drugs is common in secondary-school and first-year university syllabi. It links to neighbouring topics Experimental psychiatric drugs, Lists of investigational drugs, Obsessive–compulsive disorder, so understanding it makes those chapters shorter.
In everyday life: Look for List of investigational obsessive–compulsive disorder drugs outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

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